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m-Imodobenzylguanidine is a norephinephrine analog anti-tumor agent and radiopharmaceutical in its radioiodinated form. Has shown anti-tumor effects on L1210 leukemia and N1E1115 neuroblastoma. Useful for diagnosing and treating adrenergic/neuroendocrine. Blocks ADP-ribosylation-dependent signal transduction pathways.
1. Smets, L.A., et al. 1988. Cancer Chemother. Pharmacol. 21: 9-13. PMID: 3342472
2. Loesberg, C., et al. 1990. Biochim. Biophys. Acta. 1037: 92-99. PMID: 2104758
3. Postema, E.J., et al. 2009. Cancer Biother. Radiopharm. 24: 519-525. PMID: 19877881
4. Kobayashi, S., et al. 2009. Psychiatry Res. 174: 76-80. PMID: 19766460
See how others have used m-Iodobenzylguanidine hemisulfate salt. Click on the entry to view the PubMed entry .
PMID: # 20085326 Gourand, F. et al. 2010. J. Med. Chem. 53: 1281-1287.
PMID: # 2143421 Smets, LA. et al. 1990. Biochim. Biophys. Acta. 1054: 49-55.
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