Lysophosphatidic acid (LPA) is an endogenous glycerophospholipid signaling molecule and ligand activator for EDG-2 and EDG-4 (LPA) receptors. Signaling associated with LPA has been reported to stimulate growth of fibroblasts, vascular smooth muscle cells, endothelial cells, and keratinocytes. Lysophosphatidic Acid has been indicated as both a proliferative and anti-apoptotic factor, signaling for Pl3K-mediated regulation of cell activity. Lysophosphatidic Acid has also been described to potentiate acetylchloine receptor currents by G-protein-mediated activation of Ca2+-dependent/independent protein kinase C. Lysophosphatidic Acid can bind to one of four G-protein linked receptors to mediate a variety of biological responses including smooth muscle contraction, cell proliferation, neutrite retraction and platelet aggregation.
1. Moolenaar, W H., et al., 1995. Lysophosphatidic acid, a multifunctional phospholipid messenger. The Journal of biological chemistry. 270(22): 12949-52. PMID: 7768880
2. Levine, J S., et al., 1997. Lysophosphatidic acid: a novel growth and survival factor for renal proximal tubular cells. The American journal of physiology. 273(4 Pt 2): F575-85. PMID: 9362335
3. Nishizaki, T., et al., 1997. Lysophosphatidic acid potentiates ACh receptor currents by G-protein-mediated activation of protein kinase C. Brain research. Molecular brain research. 50(1-2): 121-6. PMID: 9406926
See how others have used Lysophosphatidic Acid (CAS 325465-93-8). Click on the entry to view the PubMed entry .
PMID: # 33558623 Malek, N.|Michrowska, A.|Mazurkiewicz, E.|Mrówczyńska, E.|Mackiewicz, P.|Mazur, AJ.| et al. 2021. Sci Rep. 11: 3329.
PMID: # 33571521 Lu, J.|Hu, Z.|Deng, Y.|Wu, Q.|Wu, M.|Song, H.| et al. 2021. J Biol Chem. 100400.
PMID: # 30840161 Olianas, MC.|Dedoni, S.|Onali, P.| et al. 2019. Apoptosis.
PMID: # 30535430 2019. Int. J. Oncol. 54: 515-526.
PMID: # 31145906 Xu, L.|Su, J.|Guo, L.|Wang, S.|Deng, X.|Ma, S.| et al. 2019. Neuropharmacology. 155: 150-161.
PMID: # 31010479 Jobst-Schwan, T.|Hoogstraten, CA.|Kolvenbach, CM.|Schmidt, JM.|Kolb, A.|Eddy, K.|Schneider, R.|Ashraf, S.|Widmeier, E.|Majmundar, AJ.|Hildebrandt, F.| et al. 2019. Kidney Int. 95: 1079-1090.
PMID: # 29856906 Zhang, R.|Wang, J.| et al. 2018. Cancer Sci. 109: 2446-2457.
PMID: # 27754741 Handa, H.|Hashimoto, A.|Hashimoto, S.|Sabe, H.| et al. 2018. Small GTPases. 9: 420-426.
PMID: # 30031609 Lu, S. et al. 2018. Biochem. Biophys. Res. Commun. 503: 1322-1329.
PMID: # 30385786 Deng, Y.|Lu, J.|Li, W.|Wu, A.|Zhang, X.|Tong, W.|Ho, KK.|Qin, L.|Song, H.|Mak, KK.| et al. 2018. Nat Commun. 9: 4564.
Santa Cruz Biotechnology, Inc. is a world leader in the development of products for the biomedical research market. Call us Toll Free at 1-800-457-3801.
Copyright © 2007-2021 Santa Cruz Biotechnology, Inc. All Rights Reserved. "Santa Cruz Biotechnology", and the Santa Cruz Biotechnology, Inc. logo, "Santa Cruz Animal Health", "San Juan Ranch", "Supplement of Champions", the San Juan Ranch logo, "Ultracruz", "Chemcruz", "Immunocruz", "Exactacruz", and "EZ Touch" are registered trademarks of Santa Cruz Biotechnology, Inc.
All trademarks are the property of their respective owners.