Lomustine (CAS 13010-47-4)

5.0(1)

Skriv en recension Ställ en fråga

See product citations (1)

Alternativa namn: 1-(2-Chloroethyl)-3-cyclohexyl-1-nitrosourea; Belustine; Cecenu; CeeNU; CINU

Ansökan Lomustine is an alkylating antitumor nitrosourea agent

CAS Nr: 13010-47-4

Renhet: ≥97%

Molekylvikt: 233.70

Molekylär formel: C₉H₁₆CIN₃O₂

Kompletterande information: This is classified as a Dangerous Good for transport and may be subject to additional shipping charges.

For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.

* Refer to Certificate of Analysis for lot specific data (including water content).

QUICK LINKS

Click on image or enlarge button to enlarge

Lomustine is an alkylating nitrosourea compound that possesses antitumor activity similar to Carmustine (sc-204671) causing DNA interstrand cross-linking. The compound is also a documented inhibitor of glutathione reductase, DLD(lipoamide dehydrogenase) and trypanothione reductase. Lomustine is a highly lipid soluble compound thus enabling it to cross the blood brain barrier and rapidly disperse in tissue. In A2870 cells, Lomustine has been shown to induce p53 expression.

Konferenser

1. Dean, S.W., et al. 1986. Biochem. Pharmacol. 35: 1171-1176. PMID: 2938589
2. Hartley, J.A., et al. 1986. Cancer Res. 46: 1943-1947. PMID: 3004713
3. Brent, T.P. 1986. Cancer Res. 46: 2320-2323. PMID: 2938727
4. Aquilina, G., et al. 2000. Clin. Cancer Res. 6: 671-680. PMID: 10690553

Physical State :

Solid

Solubility :

Soluble in ethanol (47 mg/ml at 25° C), chloroform, water (<1 mg/ml at 25° C), DMSO (47 mg/ml at 25° C), and acetone.

LAGRING :

Store at 4° C

Melting Point :

88-90° C

Boiling Point :

354.07° C (Predicted)

Density :

1.35 g/cm3

Refractive Index :

n²⁰_D 1.58

IC50 :

Growth of ZR-75-1: IC₅₀ = 12 µM; Growth of U373: IC₅₀ = 15 µM; HIV-1(RF): IC₅₀ = 42.7 µM (CEM); HIV-1(RF): EC₅₀50 >250 µM (CEM)

pK Values :

pK_a: 10.88 (Predicted)

For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.

WGK Germany :

RTECS :

YS4900000

PubChem CID :

3950

Merck Index :

14: 5564

MDL Number :

MFCD00012392

EC Number :

235-859-2

Beilstein Registry :

2125058

SMILES :

C1CCC(CC1)NC(=O)N(CCCl)N=O

Download SDS (MSDS)

Certificate of Analysis

Adobe Acrobat Reader is required to reliably view,
print and comment on PDF documents

Lomustine (CAS 13010-47-4) Produkt Citat

See how others have used Lomustine (CAS 13010-47-4). Click on the entry to view the PubMed entry .

Citations 1 to 1 of 1 total

Citations 1 to 1 of 1 total

Choose a Store

Choose a Language

Choose a Currency