Lomustine is an alkylating nitrosourea compound that possesses antitumor activity similar to Carmustine (sc-204671) causing DNA interstrand cross-linking. The compound is also a documented inhibitor of glutathione reductase, DLD(lipoamide dehydrogenase) and trypanothione reductase. Lomustine is a highly lipid soluble compound thus enabling it to cross the blood brain barrier and rapidly disperse in tissue. In A2870 cells, Lomustine has been shown to induce p53 expression.
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See how others have used Lomustine (CAS 13010-47-4). Click on the entry to view the PubMed entry .
PMID: # 31375673 Oellerich, T.|Schneider, C.|Thomas, D.|Knecht, KM.|Buzovetsky, O.|Kaderali, L.|Schliemann, C.|Bohnenberger, H.|Angenendt, L.|Hartmann, W.|Wardelmann, E.|Rothenburger, T.|Mohr, S.|Scheich, S.|Comoglio, F.|Wilke, A.|Ströbel, P.|Serve, H.|Michaelis, M.|Ferreirós, N.|Geisslinger, G.|Xiong, Y.|Keppler, OT.|Cinatl, J.| et al. 2019. Nat Commun. 10: 3475.
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