Lomustine CAS: 13010-47-4
MF: C9H16CIN3O2
MW: 233.70
An alkylating antitumor nitrosourea agent.

Lomustine (CAS 13010-47-4)

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Alternativa namn: 1-(2-Chloroethyl)-3-cyclohexyl-1-nitrosourea; Belustine; Cecenu; CeeNU; CINU
Ansökan Lomustine is an alkylating antitumor nitrosourea agent
CAS Nr: 13010-47-4
Renhet: ≥97%
Molekylvikt: 233.70
Molekylär formel: C9H16CIN3O2
Kompletterande information: This is classified as a Dangerous Good for transport and may be subject to additional shipping charges.
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data (including water content).

Lomustine is an alkylating nitrosourea compound that possesses antitumor activity similar to Carmustine (sc-204671) causing DNA interstrand cross-linking. The compound is also a documented inhibitor of glutathione reductase, DLD(lipoamide dehydrogenase) and trypanothione reductase. Lomustine is a highly lipid soluble compound thus enabling it to cross the blood brain barrier and rapidly disperse in tissue. In A2870 cells, Lomustine has been shown to induce p53 expression.


Konferenser

1. Dean, S.W., et al. 1986. Biochem. Pharmacol. 35: 1171-1176. PMID: 2938589
2. Hartley, J.A., et al. 1986. Cancer Res. 46: 1943-1947. PMID: 3004713
3. Brent, T.P. 1986. Cancer Res. 46: 2320-2323. PMID: 2938727
4. Aquilina, G., et al. 2000. Clin. Cancer Res. 6: 671-680. PMID: 10690553

Physical State :
Solid
Solubility :
Soluble in ethanol (47 mg/ml at 25° C), chloroform, water (<1 mg/ml at 25° C), DMSO (47 mg/ml at 25° C), and acetone.
LAGRING :
Store at 4° C
Melting Point :
88-90° C
Boiling Point :
354.07° C (Predicted)
Density :
1.35 g/cm3
Refractive Index :
n20D 1.58
IC50 :
Growth of ZR-75-1: IC50 = 12 µM; Growth of U373: IC50 = 15 µM; HIV-1(RF): IC50 = 42.7 µM (CEM); HIV-1(RF): EC5050 >250 µM (CEM)
pK Values :
pKa: 10.88 (Predicted)
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
WGK Germany :
3
RTECS :
YS4900000
PubChem CID :
Merck Index :
14: 5564
MDL Number :
MFCD00012392
EC Number :
235-859-2
Beilstein Registry :
2125058
SMILES :
C1CCC(CC1)NC(=O)N(CCCl)N=O

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Certificate of Analysis

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Lomustine (CAS 13010-47-4)  Produkt Citat

See how others have used Lomustine (CAS 13010-47-4). Click on the entry to view the PubMed entry .

Citations 1 to 1 of 1 total

PMID: # 31375673  Oellerich, T.|Schneider, C.|Thomas, D.|Knecht, KM.|Buzovetsky, O.|Kaderali, L.|Schliemann, C.|Bohnenberger, H.|Angenendt, L.|Hartmann, W.|Wardelmann, E.|Rothenburger, T.|Mohr, S.|Scheich, S.|Comoglio, F.|Wilke, A.|Ströbel, P.|Serve, H.|Michaelis, M.|Ferreirós, N.|Geisslinger, G.|Xiong, Y.|Keppler, OT.|Cinatl, J.| et al. 2019. Nat Commun. 10: 3475.

Citations 1 to 1 of 1 total
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