Lansoprazole CAS: 103577-45-3
MF: C16H14F3N3O2S
MW: 369.36
An H+,K+-ATPase inhibitor that displays antisecretory activity.

Lansoprazole (CAS 103577-45-3)

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Ansökan Lansoprazole is a H+,K+-ATPase inhibitor that displays antisecretory activity
CAS Nr: 103577-45-3
Renhet: ≥98%
Molekylvikt: 369.36
Molekylär formel: C16H14F3N3O2S
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data (including water content).
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Lansoprazole is a ATP4A (H+,K+-ATPase) inhibitor (IC50 = 6.3 μM) that displays antisecretory and antiulcer activity. Inhibits gastric acid secretion (IC50 = 0.09 µM for histamine-induced acid formation) and reduces gastric lesion formation induced by a variety of ulcerative stimuli. Antibacterial against Helicobacter pylori in vitro. Also blocks swelling-dependent chloride channel (ICI swell) in NIH3T3 fibroblasts. Lansoprazole is more potent than omeprazole (sc-202265).


Konferenser

Satoh et al (1989) Antisecretory and antiulcer activities of a novel proton pump inhibitor AG-1749 in dogs and rats. J.Pharmacol.Exp.Ther. 248 806. Schmarda et al (2000 The gastric H,K-ATPase blocker lansoprazole is an inhibitor of chloride channels. Br.J.Pharmacol. 129 598. Matheson and Jarvis (2001) Lansoprazole. Drugs 61 1801.

Physical State :
Solid
Solubility :
Soluble in methanol, ethanol (14 mg/ml at 25° C), DMF (~30 mg/ml), and DMSO (74 mg/ml at 25° C). Insoluble in water.
LAGRING :
Store at 4° C
Refractive Index :
n20D 1.64 (Predicted)
IC50 :
Giardia intestinalis: IC50 = 73.1 nM; Trichomonas vaginalis: IC50 = 121.8 nM; CYP2C19: IC50 = 336.7 nM (human); Entamoeba histolytica: IC50 = 346.6 nM; PHOSPHO1: IC50 = 434 nM (human)
pK Values :
pKa: pK1: 1.1 (Predicted), pK2: 6.9 (Predicted), pK3: 12 (Predicted), pKb: 1.97 (Predicted)
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
WGK Germany :
2
RTECS :
DD9487500
PubChem CID :
Merck Index :
14: 5362
MDL Number :
MFCD00866873
Beilstein Registry :
4333393
SMILES :
CC1=C(C=CN=C1CS(=O)C2=NC3=CC=CC=C3N2)OCC(F)(F)F

Download SDS (MSDS)

Certificate of Analysis

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Lansoprazole (CAS 103577-45-3)  Produkt Citat

See how others have used Lansoprazole (CAS 103577-45-3). Click on the entry to view the PubMed entry .

Citations 1 to 4 of 4 total

PMID: # 25141173  Novotna, A. et al. 2014. PLoS ONE. 9: e105580.

PMID: # 24887303  Novotna, A. et al. 2014. PLoS ONE. 9: e98711.

PMID: # 23652407  Tamraz, B. et al. 2013. Pharmacogenet. Genomics. 23: 355-64.

PMID: # 32153057  Andrologia. e13564.

Citations 1 to 4 of 4 total
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