ITSA1 CAS: 200626-61-5
MF: C13H7Cl2N3O
MW: 292.12
An HDAC activator via TSA suppression.

ITSA1 (CAS 200626-61-5)

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Synonym: N-(1H-Benzotriazol-1-yl)-2,4-dichlorobenzamide;1-(2,4-Dichlorobenzoyl)-1H-benzotriazole
Ansökan An HDAC activator via TSA suppression
Momsregistreringsnummer :: 200626-61-5
Purity: 98%
Molecular Weight: 292.12
Molecular Formula: C13H7Cl2N3O
* Refer to Certificate of Analysis for lot specific data (including water content).
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ITSA1 (N-(1H-Benzotriazol-1-yl)-2,4-dichlorobenzamide) is an HDAC activator via TSA suppression, but shows no activity towards other HDAC inhibitors. TSA (Trichostatin A) is an inhibitor of histone deacetylase. ITSA1 was found to specifically counteract TSA-induced cell cycle arrest, histone acetylation, transcriptional activation, and cytoplasmic alpha-tubulin acetylation.


Konferenser

1. Haggarty, S.J., et al. 2003. Chem. Biol. 10: 1267-1279. PMID: 14700634
2. Koeller, K.M., et al. 2003. Chem. Biol. 10: 397-410. PMID: 12770822

Physical State :
Solid
Solubility :
Soluble in DMSO (25 mg/mL).
LAGRING :
Store at 4° C
Melting Point :
172.79° C
Boiling Point :
483.41° C at 760 mmHg
Density :
1.52 g/cm3
Refractive Index :
n20D 1.71
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
WGK Germany :
3
PubChem CID :
771910
MDL Number :
MFCD00195103
SMILES :
C1=CC=C2C(=C1)N=NN2C(=O)C3=C(C=C(C=C3)Cl)Cl

Download SDS (MSDS)

Certificate of Analysis

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