Anti-IGFBP3 Antibody (E-9) is a mouse monoclonal IgG1 (kappa light chain) IGFBP3 antibody provided at 200 µg/ml
raised against amino acids 113-210 of IGFBP3 of human origin
IGFBP3 Antibody (E-9) is recommended for detection of precursor and mature IGFBP3 of human origin by WB, IP, IF and ELISA
Anti-IGFBP3 Antibody (E-9) is available conjugated to agarose for IP; HRP for WB, IHC(P) and ELISA; and to either phycoerythrin or FITC for IF, IHC(P) and FCM
also available conjugated to Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594 or Alexa Fluor® 647 for WB (RGB), IF, IHC(P) and FCM, and for use with RGB fluorescent imaging systems, such as iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
also available conjugated to Alexa Fluor® 680 or Alexa Fluor® 790 for WB (NIR), IF and FCM; for use with Near-Infrared (NIR) detection systems, such as LI-COR®Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
Contact our Technical Service Department (or your local Distributor) for more information on how to receive a FREE 10 µg sample of IGFBP3 (E-9): sc-374365.
m-IgGκ BP-HRP (mouse IgGκ binding protein-HRP) is the preferred detection reagent for IGFBP3 Antibody (E-9) for WB applications. This reagent is now offered in a bundle with IGFBP3 Antibody (E-9) (see ordering information below). For additional m-IgGκ BP conjugates see our complete list of Mouse IgG Binding Proteins.
Every item is shipped based on the best shipping method assessed for the temperature requirements of that specific item. Items are grouped and shipped together whenever
possible, and a separate shipping charge will be included for each shipping method required. Shipping charges listed below are from our US warehouses to the Contiguous US,
Alaska, Hawaii, Canada and Puerto Rico. Shipping charges for countries outside the US and Canada will be determined once order has been received
Please note: We can not ship to PO boxes
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SHIPPING METHODS & CHARGES
Ships via FedEx Ground to Contiguous US, Alaska, Canada, Monday through Friday. This method is used for less temperature sensitive items such as lab ware and animal
health products, bulky and/or heavy items
Labware ships FedEx Ground free of charge to the contiguous US
IGFBP3 Antibody (E-9) is a high quality monoclonal IGFBP3 antibody (also designated IBP3 antibody) suitable for the detection of the IGFBP3 protein of human origin. IGFBP3 Antibody (E-9) is available as both the non-conjugated anti-IGFBP3 antibody form, as well as multiple conjugated forms of anti-IGFBP3 antibody, including agarose, HRP, PE, FITC and multiple Alexa Fluor® conjugates. The Insulin-like growth factor-binding proteins (IGFBPs), a family of homologous proteins that have co-evolved with the IGFs, serve not only as shuttle molecules for the soluble IGFs, but also confer a level of regulation to the IGF signaling system. Physical association of the IGFBPs with IGF influences the bio-availability of the growth factors, and their concentration and distribution in the extracellular environment. The IGFBPs also appear to have biological activity independent of the IGFs. Seven IGFBPs have been described, each differing in their tissue distribution, half-lives and modulation of IGF interactions with their receptors. IGFBP1 is negatively regulated by Insulin production. The IGFBP1 gene is expressed at a high level during fetal liver development and in response to nutritional changes and diabetes. IGFBP2, which may function as a chaperone, escorting IGFs to their target tissues, is expressed in several human tissues including fetal eye and fetal brain. IGFBP3, the most abundant IGFBP, is complexed with roughly 80% of the serum IGFs. Both IGFBP3 and IGFBP4 are released by dermal fibroblasts in response to incision injury. IGFBP5 is secreted by myoblasts and may play a key role in muscle differentiation. IGFBP6 differs from other IGFBPs in having the highest affinity for IGF-II. Glycosylated human IGFBP6 is expressed in Chinese hamster ovary (CHO) cells, whereas non-glycosylated recombinant human IGFBP-6 is expressed in E. coli. IGFBP7, a secreted protein that binds both IGF-I and IGF-II with a relatively low affinity, stimulates prostacyclin production and may also function as a growth-suppressing factor.
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
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