Idebenone CAS: 58186-27-9
MF: C19H30O5
MW: 338.44
An antioxidant and neuroprotective agent.

Idebenone (CAS 58186-27-9)

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Synonym: 2-(10-Hydroxydecyl)-5,6-dimethoxy-3-methyl-2,5-cyclohexadiene-1,4-dione
Ansökan An antioxidant and neuroprotective agent
Momsregistreringsnummer :: 58186-27-9
Purity: ≥98%
Molecular Weight: 338.44
Molecular Formula: C19H30O5
* Refer to Certificate of Analysis for lot specific data (including water content).
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Idebenone, a neuroprotective agent, has been shown to act as a free radical scavenger and protect mitochondrial membranes against lipid peroxidation. This compound has also been found to prevent platelet aggregation and recover cholinergic and monoaminergic changes in murine models. Other studies show that Idebenone displays a capacity to increase nerve growth factor production in cultured rat astrocytes. Additionally, this agent has been reported to dose-dependently inhibit enzymatic metabolism of Arachidonic Acid (sc-200770) in astroglial homogenates.


Konferenser

1. Zs -Nagy, I. 1990. Arch Gerontol Geriatr. 11: 177-186. PMID: 15374467
2. Civenni, G., et al. 1999. Eur. J. Pharmacol. 370: 161-167. PMID: 10323265
3. Takuma, K., et al. 2000. Eur. J. Pharmacol. 406: 333-339. PMID: 11040339

Physical State :
Solid
Solubility :
Soluble in DMSO (>25 mg/ml), ethanol (>25 mg/ml), methanol, and chloroform. Insoluble in water.
LAGRING :
Store at room temperature
Melting Point :
~192.68° C (Predicted)
Boiling Point :
~497.3° C at 760 mmHg (Predicted)
Density :
~1.1 g/cm3 (Predicted)
Refractive Index :
n20D 1.50
IC50 :
Rattus norvegicus: IC50 = 1300 nM (Rattus norvegicus); Brain: IC50 = 31500 nM (Rattus norvegicus)
pK Values :
pKa: 15.19
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
WGK Germany :
3
RTECS :
GU5290000
PubChem CID :
3686
Merck Index :
14: 4888
MDL Number :
MFCD00274552
Beilstein Registry :
2001459
SMILES :
CC1=C(C(=O)C(=C(C1=O)OC)OC)CCCCCCCCCCO

Download SDS (MSDS)

Certificate of Analysis

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Idebenone  Produkt Citat

See how others have used Idebenone. Click on the entry to view the PubMed entry .

Citations 1 to 2 of 2 total

PMID: # 9840428  Hirai, K. et al. 1998. Naunyn Schmiedebergs Arch. Pharmacol. 358: 582-585.

PMID: # 31783691  Cancers (Basel). 11:

Citations 1 to 2 of 2 total
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