Anti-hnRNP I Antibody (SH54) is a mouse monoclonal IgG1 κ hnRNP I antibody, cited in 10 publications, provided at 200 µg/ml
raised against HeLa nuclear extract of human origin
hnRNP I Antibody (SH54) is recommended for detection of hnRNP I of human origin by WB, IP, IF and IHC(P)
Anti-hnRNP I Antibody (SH54) is available conjugated to agarose for IP; HRP for WB, IHC(P) and ELISA; and to either phycoerythrin or FITC for IF, IHC(P) and FCM
also available conjugated to Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594 or Alexa Fluor® 647 for WB (RGB), IF, IHC(P) and FCM, and for use with RGB fluorescent imaging systems, such as iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
also available conjugated to Alexa Fluor® 680 or Alexa Fluor® 790 for WB (NIR), IF and FCM; for use with Near-Infrared (NIR) detection systems, such as LI-COR®Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
Contact our Technical Service Department (or your local Distributor) for more information on how to receive a FREE 10 µg sample of hnRNP I (SH54): sc-56701.
m-IgG Fc BP-HRP (mouse IgG Fc binding protein-HRP) and m-IgGκ BP-HRP (mouse IgGκ binding protein-HRP) are the preferred secondary detection reagents for hnRNP I Antibody (SH54) for WB and IHC(P) applications. These reagents are now offered in bundles with hnRNP I Antibody (SH54) (see ordering information below).
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Labware ships FedEx Ground free of charge to the contiguous US
hnRNP I Antibody (SH54) is a high quality monoclonal hnRNP I antibody (also designated PTBP1 antibody, or PTB antibody) suitable for the detection of the hnRNP I protein of human origin. hnRNP I Antibody (SH54) is available as both the non-conjugated anti-hnRNP I antibody form, as well as multiple conjugated forms of anti-hnRNP I antibody, including agarose, HRP, PE, FITC and multiple Alexa Fluor® conjugates. Heterogeneous nuclear ribonucleoproteins (hnRNPs) constitute a set of polypeptides that contribute to mRNA transcription and pre-mRNA processing as well as mature mRNA transport to the cytoplasm and translation. They also bind heterogeneous nuclear RNA (hnRNA), which are the transcripts produced by RNA polymerase II. There are approximately 20 known hnRNP proteins, and their complexes are the major constituents of the spliceosome. The majority of hnRNP proteins components are localized to the nucleus; however some shuttle between the nucleus and the cytoplasm. hnRNP I, also designated polypyrimidine tract-binding protein (PTB), and its homolog hnRNP L bind to the 3′ end of introns to modulate alternative splicing mechanisms of pre-mRNAs in normal cells and the translation of several viruses, including hepatitis C virus (HCV). The human hnRNP I gene maps to chromosome 19p13.3 and encodes a protein that is localized in the nucleoplasm. hnRNP L like hnRNP I, is also localized in the nucleoplasm.
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
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To place an order using RMB or to ship to mainland China, please visit www.scbio.cn