Every item is shipped based on the best shipping method assessed for the temperature requirements of that specific item. Items are grouped and shipped together whenever
possible, and a separate shipping charge will be included for each shipping method required. Shipping charges listed below are from our US warehouses to the Contiguous US,
Alaska, Hawaii, Canada and Puerto Rico. Shipping charges for countries outside the US and Canada will be determined once order has been received
Please note: We can not ship to PO boxes
Express Blue Ice
Express Dry Ice
Animal Health Prescription Item
SHIPPING METHODS & CHARGES
Ships via FedEx Ground to Contiguous US, Alaska, Canada, Monday through Friday. This method is used for less temperature sensitive items such as lab ware and animal
health products, bulky and/or heavy items
Labware ships FedEx Ground free of charge to the contiguous US
HIRA Antibody (374C6a) is a high quality monoclonal HIRA antibody (also designated HIRA antibody) suitable for the detection of the HIRA protein of mouse, rat and human origin. HIRA Antibody (374C6a) is available as the non-conjugated anti-HIRA antibody. HIRA is the human homolog of yeast Hir1p and Hir2p and is a widely expressed nuclear protein involved in cell cycle regulation. Specifically, HIRA is essential during development, possibly through the control of specific gene transcription programs. During development, HIRA is highly expressed in regions that contain neural crest cells. Cyclin dependent kinase 2 (Cdk-2) and Cyclin A bind with HIRA at an RXL motif which results in phosphorylation of the substrate at Thr 555. Ectopic expression of HIRA results in cell cycle arrest in S phase. HIRA also contains seven copies of a WD repeat and exhibits histone binding properties, suggesting that it may function as a regulator of histone gene expression. The gene encoding the 1017 amino acid HIRA maps to human chromosome 22q11, an area known to be the critical region of DiGeorge Syndrome (DGS). DGS is a congenital disease characterized by defects in tissues and organs, whose development depends on cell populations derived from the neural crest.
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.