HDS 029 CAS: 881001-19-0
MF: C17H11ClFN5O
MW: 355.76
A potent inhibitor of EGF receptor family.

HDS 029 (CAS 881001-19-0)

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Alternativa namn: EGFR/ErbB-2/ErbB-4 Inhibitor
Ansökan HDS 029 is A potent inhibitor of EGF receptor family
Momsregistreringsnummer :: 881001-19-0
Purity: ≥95%
Molecular Weight: 355.76
Molecular Formula: C17H11ClFN5O
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data (including water content).

HDS 029 is a potent inhibitor of the ErbB receptor family (IC50 values are 0.3, 0.5 and 1.1 nM for EGFR (ErbB1), ErbB-4 (ErbB4) and Neu (ErbB2) respectively). It inhibits EGF-induced EGFR (erbB1) autophosphorylation in NIH3T3 cells and heregulin-stimulated ErbB autophosphorylation in MDA-MB-453 human breast carcinoma cells (IC50 values are 2.5 and 24 nM respectively).


Konferenser

Klutchko et al (2006) Tyrosine kinase inhibitors. 19. 6-alkynamides of 4-anilinoquinazolines and 4-aniliopyrido[3,4-d]pyrimidines as irreversible inhibitors of the erbB family of tyrosine kinase receptors. J.Med.Chem. 49 1475.

Appearance :
Powder
Physical State :
Solid
Solubility :
Soluble in DMSO (25 mM).
LAGRING :
Store at -20° C
Density :
~1.5 g/cm3 (Predicted)
Refractive Index :
n20D 1.74 (Predicted)
IC50 :
EGFR: IC50 = 0.3 nM (human); ErbB-4: IC50 = 0.5 nM (human); Neu: IC50 = 1.1 nM (human); EGF-induced erbB1 autophosphorylation: IC50 = 2.5 nM (NIH3T3 cells); Heregulin-stimulated ErbB autophosphorylation: IC50 = 24 nM (MDA-MB-453 human breast carcinoma cells)
pK Values :
pKa: 7.46 (Predicted), pKb: 3.59 (Predicted)
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
PubChem CID :
11566580
MDL Number :
MFCD09971110
SMILES :
CC#CC(=O)NC1=NC=C2C(=C1)C(=NC=N2)NC3=CC(=C(C=C3)F)Cl

Download SDS (MSDS)

Certificate of Analysis

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