Anti-HCP1 Antibody (B-4) is a mouse monoclonal IgG1 κ HCP1 antibody, cited in 3 publications, provided at 200 µg/ml
specific for an epitope mapping between amino acids 432-459 at the C-terminus of HCP1 of human origin
Anti-HCP1 Antibody (B-4) is recommended for detection of HCP1 of mouse, rat and human origin by WB, IP, IF, IHC(P) and ELISA
Anti-HCP1 Antibody (B-4) is available conjugated to agarose for IP; HRP for WB, IHC(P) and ELISA; and to either phycoerythrin or FITC for IF, IHC(P) and FCM
also available conjugated to Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594 or Alexa Fluor® 647 for WB (RGB), IF, IHC(P) and FCM, and for use with RGB fluorescent imaging systems, such as iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
also available conjugated to Alexa Fluor® 680 or Alexa Fluor® 790 for WB (NIR), IF and FCM; for use with Near-Infrared (NIR) detection systems, such as LI-COR®Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
Contact our Technical Service Department (or your local Distributor) for more information on how to receive a FREE 10 µg sample of HCP1 (B-4): sc-393460.
m-IgG1 BP-HRP and m-IgGκ BP-HRP are the preferred secondary detection reagents for HCP1 Antibody (B-4) for WB and IHC(P) applications. These reagents are now offered in bundles with HCP1 Antibody (B-4) (see ordering information below).
Every item is shipped based on the best shipping method assessed for the temperature requirements of that specific item. Items are grouped and shipped together whenever
possible, and a separate shipping charge will be included for each shipping method required. Shipping charges listed below are from our US warehouses to the Contiguous US,
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Ships via FedEx Ground to Contiguous US, Alaska, Canada, Monday through Friday. This method is used for less temperature sensitive items such as lab ware and animal
health products, bulky and/or heavy items
Labware ships FedEx Ground free of charge to the contiguous US
HCP1 Antibody (B-4) is a high quality monoclonal HCP1 antibody (also designated HCP1 antibody) suitable for the detection of the HCP1 protein of mouse, rat and human origin. HCP1 Antibody (B-4) is available as both the non-conjugated anti-HCP1 antibody form, as well as multiple conjugated forms of anti-HCP1 antibody, including agarose, HRP, PE, FITC and multiple Alexa Fluor® conjugates. HCP1 (Heme carrier protein 1), also known as proton-coupled folate transporter (PCFT), is a multi-pass transmembrane protein that is expressed in the small intestine. It is predominantly found in the duodenum and the jejunum localizing to the apical brush border. HCP1 is required for normal folate absorption in the intestine and is associated with folate homeostasis. HCP1 mediates the transport of folate and functions most optimally at a low extracellular pH of approximately 5.5. HCP1 functions independently of Na+ and is insensitive to membrane potential. It exhibits high affinity for folic acid and low affinity for the PT523 antifolate. HCP1 is post-translationally regulated by iron levels in the duodenum. During iron deficiency, HCP1 localizes to the apical membrane; however, iron excess causes HCP1 to localize in the cytoplasm. Sulfasalazine is a potent inhibitor of HCP1. Mutations in the gene encoding HCP1 can result in the autosomal recessive disorder hereditary folate malabsorption (HFM).
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
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