GTP 14564 CAS: 34823-86-4
GTP 14564 is a specific inhibitor of class III receptor tyrosine kinases.

GTP 14564 (CAS 34823-86-4)

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Ansökan GTP 14564 is a specific inhibitor of class III receptor tyrosine kinases
Momsregistreringsnummer :: 34823-86-4
Purity: >98%
Molecular Weight: 234.26
Molecular Formula: C15H10N2O
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data (including water content).

GTP 14564 is a cell-permeable tricyclic benzofurano-indazolo compound which functions as a specific inhibitor of class III receptor tyrosine kinases. Studies show that GTP 14564 can be used to track the signaling pathways activated by FLT3 and ITD-FLT3 in Ba/F3 cells. Furthermore, GTP 14564 can suppress the FLT3 internal tandem duplication (ITD) cells to the same extent as FLT3 siRNA. Studies show that if combined with 17-AAG, GTP 14564 can reduce the levels of p-FLT3 and p-STAT5 and can amplify apoptosis and G0/G1 arrest in FLT3-ITD cells. GTP 14564 is an inhibitor of c-Fms-CSF-1R, c-Kit, Flt-3/Flk-2 and PDGFR-beta.


Konferenser

1. Murata, K. et al. 2003. J. Biol. Chem. 278(35): 32892-32898. PMID: 12815052

2. Yao, Q. et al. 2005. Leukemia. 19(9): 1605-1612. PMID: 16034464

Physical State :
Solid
Solubility :
Soluble in DMSO (100 mM), and ethanol (25 mM).
LAGRING :
Store at 4° C
Melting Point :
174.96° C (Predicted)
Boiling Point :
~459.1° C at 760 mmHg (Predicted)
Density :
~1.3 g/cm3 (Predicted)
Refractive Index :
n20D 1.74 (Predicted)
IC50 :
c-Fms: IC50 = 0.3 µM; c-Kit: IC50 = 0.3 µM; wt-FLT3 : IC50 = 0.3 µM; ITD-FLT3: IC50 = 0.3 µM; PDGFRβ: IC50 = 1.0 µM
pK Values :
pKa: 12.72 (Predicted), pKb: 1.57 (Predicted)
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
PubChem CID :
3385203
MDL Number :
MFCD01416326
SMILES :
C1=CC=C(C=C1)C2=NNC3=C2OC4=CC=CC=C43

Download SDS (MSDS)

Certificate of Analysis

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GTP 14564 (CAS 34823-86-4)  Produkt Citat

See how others have used GTP 14564 (CAS 34823-86-4). Click on the entry to view the PubMed entry .

Citations 1 to 3 of 3 total

PMID: # 30426699  Yang, L. et al. 2019. Mol. Plant Pathol. 20: 500-518.

PMID: # 20035824  Jacobi, A. et al. 2010. Exp. Hematol. 38: 180-190.

PMID: # 12815052  Murata, K. et al. 2003. J. Biol. Chem. 278: 32892-32898.

Citations 1 to 3 of 3 total
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