Granzyme B inhibitor is a weak inhibitor of murine and human Granzyme B. It also inhibits the apoptosis-related DNA fragmentation in lymphocytes by fragmentin 2, which is a rat lymphocyte granule protease homologous to Granzyme B (ID50 = 300 nM).
1. Gong, B., et al. 1999. Cell Growth Different. 10, 491. 2. Shi, L., et al. 1992. J. Exp. Med. 176, 1521. 3. Odake, S., et al. 1991. Biochemistry 30, 2217.