Every item is shipped based on the best shipping method assessed for the temperature requirements of that specific item. Items are grouped and shipped together whenever
possible, and a separate shipping charge will be included for each shipping method required. Shipping charges listed below are from our US warehouses to the Contiguous US,
Alaska, Hawaii, Canada and Puerto Rico. Shipping charges for countries outside the US and Canada will be determined once order has been received
Please note: We can not ship to PO boxes
Express Blue Ice
Express Dry Ice
Animal Health Prescription Item
SHIPPING METHODS & CHARGES
Ships via FedEx Ground to Contiguous US, Alaska, Canada, Monday through Friday. This method is used for less temperature sensitive items such as lab ware and animal
health products, bulky and/or heavy items
Labware ships FedEx Ground free of charge to the contiguous US
Eukaryotic cells contain three distinct prenyltransferases that catalyze the attachment of a thioether-linked 15-carbon farnesyl group or 20-carbon geranylgeranyl group to C-terminal cysteine residues. Geranylgeranyltransferase type I (GGTase-I, PGGTase-I) catalyzes the nucleophilic substitution reaction between geranylgeranyl diphosphate (GGPP) and a protein-derived thiol to form the thioether linkage. The candidate protein contains a C-terminal CAAX motif in which "A" is an aliphatic amino acid and "X" is leucine. Geranylgeranylation is necessary for the TGFβ1 signaling pathway, which involves phosphatidylcholine-specific phospholipase and a protein kinase C. Human GGTase-I contains an α subunit and a β subunit. Geranylgeranyltransferase type II (GGTase-II) is a heterodimer that catalyzes the transfer of two 20-carbon geranylgeranyl groups from geranylgeranyl pyrophosphate onto C-terminal cysteine residues of Rab GTPases, which is required for the activity of Rab proteins. GGTase-II also contains an α subunit and a β subunit.
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
To place an order using RMB or to ship to mainland China, please visit www.scbio.cn