Anti-GGTase-Iβ Antibody (D-11) is a mouse monoclonal IgG2b κ GGTase-Iβ antibody, cited in 1 publications, provided at 200 µg/ml
raised against amino acids 1-220 mapping at the N-terminus of GGTase-Iβ of human origin
Anti-GGTase-I beta Antibody (D-11) is recommended for detection of GGTase-Iβ of mouse, rat and human origin by WB, IP, IF, IHC(P) and ELISA; also reactive with additional species, including equine
Anti-GGTase-I beta Antibody (D-11) is available conjugated to agarose for IP; HRP for WB, IHC(P) and ELISA; and to either phycoerythrin or FITC for IF, IHC(P) and FCM
also available conjugated to Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594 or Alexa Fluor® 647 for WB (RGB), IF, IHC(P) and FCM, and for use with RGB fluorescent imaging systems, such as iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
also available conjugated to Alexa Fluor® 680 or Alexa Fluor® 790 for WB (NIR), IF and FCM; for use with Near-Infrared (NIR) detection systems, such as LI-COR®Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
Contact our Technical Service Department (or your local Distributor) for more information on how to receive a FREE 10 µg sample of GGTase-Iβ (D-11): sc-376854.
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GGTase-Iβ Antibody (D-11) is a high quality monoclonal GGTase-I beta antibody (also designated GGTase-Iβ antibody) suitable for the detection of the GGTase-I beta protein of mouse, rat and human origin. GGTase-Iβ Antibody (D-11) is available as both the non-conjugated anti-GGTase-I beta antibody form, as well as multiple conjugated forms of anti-GGTase-I beta antibody, including agarose, HRP, PE, FITC and multiple Alexa Fluor® conjugates. Eukaryotic cells contain three distinct prenyltransferases that catalyze the attachment of a thioether-linked 15-carbon farnesyl group or 20-carbon geranylgeranyl group to C-terminal cysteine residues. Geranylgeranyltransferase type I (GGTase-I, PGGTase-I) catalyzes the nucleophilic substitution reaction between geranylgeranyl diphosphate (GGPP) and a protein-derived thiol to form the thioether linkage. The candidate protein contains a C-terminal CAAX motif in which "A" is an aliphatic amino acid and "X" is leucine. Geranylgeranylation is necessary for the TGF-β1 signaling pathway, which involves phosphatidylcholine-specific phospholipase and a protein kinase C. Human GGTase-I contains an α subunit and a β subunit. Geranylgeranyltransferase type II (GGTase-II) is a heterodimer that catalyzes the transfer of two 20-carbon geranylgeranyl groups from geranylgeranyl pyrophosphate onto C-terminal cysteine residues of Rab GTPases, which is required for the activity of Rab proteins. GGTase-II also contains an α subunit and a β ssubunit.
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
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