Ganglioside GD1a disodium salt CAS: 12707-58-3
MF: C84H146N4O39•2Na
MW: 1882.04
An agent with a stimulatory effect on phagocytosis and phagosome-lysosome.

Ganglioside GD1a disodium salt (CAS 12707-58-3)

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Alternativa namn: Disialoganglioside GD1a•2Na
Ansökan Ganglioside GD1a disodium salt is an agent with a stimulatory effect on phagocytosis and phagosome-lysosome
CAS Nr: 12707-58-3
Renhet: 98%
Molekylvikt: 1882.04
Molekylär formel: C84H146N4O392Na
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data (including water content).
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Ganglioside GD1a disodium salt is the major ganglioside in the mammalian brain. Believed to be a differentiation marker for stem cell growth. Has shown a stimulatory effect on phagocytosis and phagosome-lysosome (P-L) fusion in a dose-dependent manner on S. aureus. Shown to modulate the Ca-dependent post-translational regulation of GAP-43. Shown to induce rapid phosphorylation of GAP-43 and stimulate ca-dependent proteolysis of GAP-43. Ganglioside GD1a disodium salt is an inhibitor of PKC.


Konferenser

1. Meiri, K.F. and Beverly, M. 1994. J. Neurochem. 62(1): 291-299. PMID: 8263528

2. Yamaguchi, S. et al. 1997. Glycoconj. J. 14(6): 707-714. PMID: 9337083

3. Yuki, N. 2010. Methods Mol. Biol. 600 : 51-65. PMID: 19882120

4. Wang, Y. et al. 2015. Int. Immunopharmacol. 28(1): 136-145. PMID: 26054879

Usage :
Supplied as a lyophilized solid.
Physical State :
Solid
LAGRING :
Store at -20° C
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
PubChem CID :
SMILES :
CCCCCCCCCCCCCCCCCC(=O)N[[email protected]@H](COC1C(C(C(C(O1)CO)OC2C(C(C(C(O2)CO)OC3C(C(C(C(O3)CO)O)OC4C(C(C(C(O4)CO)OC5(CC([[email protected]](C(O5)[[email protected]]([[email protected]](CO)O)O)NC(=O)C)O)C(=O)[O-])O)O)NC(=O)C)OC6(CC([[email protected]](C(O6)[[email protected]]([[email protected]](CO)O)O)NC(=O)C)O)C(=O)[O-])O)O)O)[[email protected]@H](/C=C/CCCCCCCCCCCCCCC)O.[Na+].[Na+]

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Certificate of Analysis

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Ganglioside GD1a disodium salt (CAS 12707-58-3)  Produkt Citat

See how others have used Ganglioside GD1a disodium salt (CAS 12707-58-3). Click on the entry to view the PubMed entry .

Citations 1 to 3 of 3 total

PMID: # 32758108  Beaver, JT.|Mills, LK.|Swieboda, D.|Lelutiu, N.|Esser, ES.|Antao, OQ.|Scountzou, E.|Williams, DT.|Papaioannou, N.|Littauer, EQ.|Skountzou, I.| et al. 2020. Hum Vaccin Immunother. 16: 2092-2108.

PMID: # 32758106  Beaver, JT.|Mills, LK.|Swieboda, D.|Lelutiu, N.|Esser, ES.|Antao, OQ.|Scountzou, E.|Williams, DT.|Papaioannou, N.|Littauer, EQ.|Romanyuk, A.|Compans, RW.|Prausnitz, MR.|Skountzou, I.| et al. 2020. Hum Vaccin Immunother. 16: 2072-2091.

PMID: # 23226505  Romero-Ramírez, L. et al. 2012. PloS one. 7: e49983.

Citations 1 to 3 of 3 total
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