Fidaxomicin CAS: 873857-62-6
MF: C52H74Cl2O18
MW: 1058.04
A macrocyclic antibiotic.

Fidaxomicin (CAS 873857-62-6)

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Fidaxomicin is rated 5.0 out of 5 by 1.
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Alternativa namn: Dificid, Dificlir
Ansökan Fidaxomicin is a macrocyclic antibiotic
Momsregistreringsnummer :: 873857-62-6
Purity: ≥98%
Molecular Weight: 1058.04
Molecular Formula: C52H74Cl2O18
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data (including water content).

Fidaxomicin is a recently approved antibiotic with a confusing history dating back to its original isolation in 1975. Fidaxomicin is the major analogue of a family of macrocyclic lactones isolated independently by three different groups from cultures belonging to three different genera (Actinoplanes, Dactylosporangium and Micromonospora) known as lipiarmycin A3, tiacumicin B and clostomicin B1, respectively. Fidaxomicin is a narrow spectrum antibiotic that works by inhibiting bacterial RNA polymerase and demonstrates excellent activity against Gram positive bacteria, notably Clostridium difficile. Fidaxomicin acts in the gastrointestinal tract without undue disruption to gut microbial flora.

Physical State :
Solid
Derived From :
Dactylosporum aurantiacum
Solubility :
Soluble in ethanol, methanol, DMF, DMSO, and Limited water solubility.
LAGRING :
Store at -20° C
Boiling Point :
~1046.4° C at 760 mmHg (Predicted)
Density :
~1.3 g/cm3 (Predicted)
Refractive Index :
n20D 1.59 (Predicted)
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
PubChem CID :
46174142
SMILES :
CC[[email protected]]1/C=C(\\[[email protected]](C/C=C/C=C(/C(=O)O[[email protected]@H](C/C=C(/C=C(/[[email protected]@H]1O[[email protected]]2[[email protected]]([[email protected]]([[email protected]@H](C(O2)(C)C)OC(=O)C(C)C)O)O)\\C)\\C)[[email protected]@H](C)O)\\CO[[email protected]]3[[email protected]]([[email protected]]([[email protected]@H]([[email protected]](O3)C)OC(=O)C4=C(C(=C(C(=C4O)Cl)O)Cl)CC)O)OC)O)/C

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Certificate of Analysis

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Fidaxomicin (CAS 873857-62-6)  Produkt Citat

See how others have used Fidaxomicin (CAS 873857-62-6). Click on the entry to view the PubMed entry .

Citations 1 to 3 of 3 total

PMID: # 30052178  Skinner, K. et al. 2018. J. Med. Microbiol. 67: 1402-1409.

PMID: # 28533232  Corbett, D. et al. 2017. Antimicrob. Agents Chemother.

PMID: # 25652750  Corbett, D. et al. 2015. J. Antimicrob. Chemother. 70: 1751-6.

Citations 1 to 3 of 3 total
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