FGF Receptor Tyrosine Kinase Inhibitor IV, NP603 MF: C26H26N2O5
MW: 446.5
A SU6668 derivative that inhibits the kinase activity of PDGFRβ, FGFR1 and VEGFR2.

FGF Receptor Tyrosine Kinase Inhibitor IV, NP603

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Ansökan FGF Receptor Tyrosine Kinase Inhibitor IV, NP603 is a SU6668 derivative that inhibits the kinase activity of PDGFRβ, FGFR1 and VEGFR2
Molecular Weight: 446.5
Molecular Formula: C26H26N2O5
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data (including water content).

FGF Receptor Tyrosine Kinase Inhibitor IV, NP603 is a cell-permeable SU6668 derivative that targets the ATP-binding pocket and inhibits the kinase activity of PDGFRβ, Flg (FGFR1) and FIk-1 (VEGFR2), while showing little activity against EGFR. NP603 exhibits anti-angiogenesis activity and suppress FGF-2-induced proliferation in HUVEC cultures in a dose-dependent manner.


Konferenser

Kammasud, N., et al. 2009. Bioorg. Med. Chem. Lett. 19, 745. Kammasud, N., et al. 2007. Bioorg. Med. Chem. Lett. 17, 4812.

Physical State :
Solid
Solubility :
Soluble in DMSO ( ≥30 mg/ml).
LAGRING :
Store at 4° C
Melting Point :
232-234° C
Boiling Point :
698.70° C at 760 mmHg (Predicted)
Density :
1.29 g/cm3 (Predicted)
Refractive Index :
n20D 1.64 (Predicted)
IC50 :
FGFR1: IC50 = 520 nM; PDGFRβ: IC50 = 780 nM; VEGFR2: IC50 = 930 nM; EGFR: IC50 = >100 µM; FGF-2-induced proliferation: IC50 = 18.2 µM (HUVEC50 cultures)
pK Values :
pKa: 4.60 (Predicted), pKb: 2.28 (Predicted)
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
WGK Germany :
3
MDL Number :
MFCD18632551
SMILES :
COc1cc(OC)cc(c1)c1ccc2c(NC(=O)/C/2=C\c2[nH]c(C)c(CCC(=O)O)c2C)c1

Download SDS (MSDS)

Certificate of Analysis

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