FGF Receptor Tyrosine Kinase Inhibitor IV, NP603 is a cell-permeable SU6668 derivative that targets the ATP-binding pocket and inhibits the kinase activity of PDGFRβ, Flg (FGFR1) and FIk-1 (VEGFR2), while showing little activity against EGFR. NP603 exhibits anti-angiogenesis activity and suppress FGF-2-induced proliferation in HUVEC cultures in a dose-dependent manner.
Kammasud, N., et al. 2009. Bioorg. Med. Chem. Lett. 19, 745. Kammasud, N., et al. 2007. Bioorg. Med. Chem. Lett. 17, 4812.
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