Anti-EXT2 Antibody (A-2) is a mouse monoclonal IgG1 κ EXT2 antibody, cited in 5 publications, provided at 200 µg/ml
raised against amino acids 402-537 mapping within an internal region of EXT2 of human origin
Anti-EXT2 Antibody (A-2) is recommended for detection of EXT2 of mouse, rat and human origin by WB, IP, IF and ELISA
Anti-EXT2 Antibody (A-2) is available conjugated to agarose for IP; HRP for WB, IHC(P) and ELISA; and to either phycoerythrin or FITC for IF, IHC(P) and FCM
also available conjugated to Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594 or Alexa Fluor® 647 for WB (RGB), IF, IHC(P) and FCM, and for use with RGB fluorescent imaging systems, such as iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
also available conjugated to Alexa Fluor® 680 or Alexa Fluor® 790 for WB (NIR), IF and FCM; for use with Near-Infrared (NIR) detection systems, such as LI-COR®Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
Contact our Technical Service Department (or your local Distributor) for more information on how to receive a FREE 10 µg sample of EXT2 (A-2): sc-514092.
m-IgGκ BP-HRP (mouse IgGκ binding protein-HRP) is the preferred detection reagent for EXT2 Antibody (A-2) for WB applications. This reagent is now offered in a bundle with EXT2 Antibody (A-2) (see ordering information below). For additional m-IgGκ BP conjugates see our complete list of Mouse IgG Binding Proteins.
Every item is shipped based on the best shipping method assessed for the temperature requirements of that specific item. Items are grouped and shipped together whenever
possible, and a separate shipping charge will be included for each shipping method required. Shipping charges listed below are from our US warehouses to the Contiguous US,
Alaska, Hawaii, Canada and Puerto Rico. Shipping charges for countries outside the US and Canada will be determined once order has been received
Please note: We can not ship to PO boxes
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SHIPPING METHODS & CHARGES
Ships via FedEx Ground to Contiguous US, Alaska, Canada, Monday through Friday. This method is used for less temperature sensitive items such as lab ware and animal
health products, bulky and/or heavy items
Labware ships FedEx Ground free of charge to the contiguous US
EXT2 Antibody (A-2) is a high quality monoclonal EXT2 antibody (also designated EXT2 antibody) suitable for the detection of the EXT2 protein of mouse, rat and human origin. EXT2 Antibody (A-2) is available as both the non-conjugated anti-EXT2 antibody form, as well as multiple conjugated forms of anti-EXT2 antibody, including agarose, HRP, PE, FITC and multiple Alexa Fluor® conjugates. Hereditary multiple exostoses (HME) is an autosomal dominant disorder characterized by the formation of exostoses (EXT), which are cartilage-capped bony protuberances mainly located on long bones. Two proteins associated with EXT, EXT1 and EXT2, form homo/heteromeric complexes in vivo, which leads to the accumulation of both proteins in the Golgi apparatus. EXT1 and EXT2 are endoplasmic reticulum-localized type II transmembrane glycoproteins that possess, or are tightly associated with, glycosyltransferase activities involved in the polymerization of the glycosaminoglycan, heparan sulfate (HS). EXT2 is a protein that harbors the D-glucuronyl (GlcA) and N-acetyl-D-glucosaminyl (GlcNAc) transferase activities required for biosynthesis of HS. EXT1 rescues defective HS biosynthesis and elevates low GlcA and GlcNAc transferase levels in mutated cells.
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
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