ErbB3/HER3 Antibody (SGP1) is a mouse monoclonal IgG1 κ, cited in 1 publications, provided at 200 µg/ml
raised against ErbB-3 purified from transfected human kidney fibroblasts
recommended for detection of the extracellular domain of ErbB-3 of mouse, rat and human origin by IP, IHC(P) and FCM
available conjugated to either phycoerythrin or FITC for IF, IHC(P) and FCM
See ErbB3/HER3 (G-4): sc-7390 for ErbB3/HER3 antibody conjugates, including AC, HRP, FITC, PE, Alexa Fluor® 488, 594, 647, 680 and 790.
m-IgG Fc BP-HRP, m-IgG1 BP-HRP and m-IgGκ BP-HRP are the preferred secondary detection reagents for ErbB3/HER3 Antibody (SGP1) for IHC(P) applications. These reagents are now offered in bundles with ErbB3/HER3 Antibody (SGP1) (see ordering information below).
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Ships via FedEx Ground to Contiguous US, Alaska, Canada, Monday through Friday. This method is used for less temperature sensitive items such as lab ware and animal
health products, bulky and/or heavy items
Labware ships FedEx Ground free of charge to the contiguous US
The EGF receptor family comprises several related receptor tyrosine kinases that are frequently overexpressed in a variety of carcinomas. Members of this receptor family include EGFR (HER1), Neu (ErbB-2, HER2), ErbB-3 (HER3) and ErbB-4 (HER4), which form either homodimers or heterodimers upon ligand binding. Full length ErbB-3 is overexpressed in human mammary tumors. The ErbB-3 gene also produces several alternative variants, including a secreted form which negatively regulates heregulin stimulated ErbB activation. ErbB-3 heterodimerizes with Neu and binds heregulin in order to activate phosphoinositide (PI) 3-kinase. The recruitment and activation of PI 3-kinase occurs via its interaction with phosphorylated YXXM motifs in the carboxy terminus of ErbB-3.
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
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