ErbB3/HER3 Antibody (2Q320) is a mouse monoclonal IgG1 κ, cited in 1 publications, provided at 200 µg/ml
epitope mapping within the cytoplasmic domain of ErbB-3 of human origin
recommended for detection of ErbB-3 of mouse, rat and human origin by WB, IP, IF, IHC(P) and FCM
See ErbB3/HER3 (G-4): sc-7390 for ErbB3/HER3 antibody conjugates, including AC, HRP, FITC, PE, Alexa Fluor® 488, 594, 647, 680 and 790.
m-IgG Fc BP-HRP and m-IgG1 BP-HRP are the preferred secondary detection reagents for ErbB3/HER3 Antibody (2Q320) for WB and IHC(P) applications. These reagents are now offered in bundles with ErbB3/HER3 Antibody (2Q320) (see ordering information below).
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Ships via FedEx Ground to Contiguous US, Alaska, Canada, Monday through Friday. This method is used for less temperature sensitive items such as lab ware and animal
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Labware ships FedEx Ground free of charge to the contiguous US
The EGF receptor family comprises several related receptor tyrosine kinases that are frequently overexpressed in a variety of carcinomas. Members of this receptor family include EGFR (HER1), Neu (ErbB-2, HER2), ErbB-3 (HER3) and ErbB-4 (HER4), which form either homodimers or heterodimers upon ligand binding. Full length ErbB-3 is overexpressed in human mammary tumors. The ErbB-3 gene also produces several alternative variants, including a secreted form of which negatively regulates heregulin stimulated ErbB activation. ErbB-3 heterodimerizes with Neu and binds heregulin in order to activate phosphoinositide (PI) 3-kinase. The recruitment and activation of PI 3-kinase occurs via its interaction with phosphorylated YXXM motifs in the carboxy terminus of ErbB-3.
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
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