EGF/FGF/PDGF Receptor Tyrosine Kinase Inhibitor is a cell-permeable and reversible protein tyrosine kinase inhibitor that inhibits human Flg (FGFR-1), PDGFR-β, c-Scr, and EGFR, meanwhile exhibiting minimal activity against InsR, PKC, or CDK4/Cyclin D1. Inhibition by EGF/FGF/PDGF Receptor Tyrosine Kinase Inhibitor is shown to be noncompetitive in the case of c-Src, but ATP-competitive in the case of Flg (FGFR-1), PDGFR-β, and EGFR.
Hamby, J.M., et al. 1997. J. Med. Chem. 40, 2296. Dahring, T.K., et al. 1997. J. Pharmacol. Exp. Ther. 281, 1446. S: 22-24/25-37-45
Soluble in DMSO (25 mg/ml), and ethanol (1 mg/ml).
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