EGF/FGF/PDGF receptor tyrosine kinase Inhibitor CAS: 1135256-66-4
MF: C18H18Cl2N6O
MW: 405.28
A tyrosine kinase inhibitor that inhibits human FGFR-1, PDGFR-β, c-Scr, & EGFR.

EGF/FGF/PDGF receptor tyrosine kinase Inhibitor (CAS 1135256-66-4)

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EGF/FGF/PDGF receptor tyrosine kinase Inhibitor is rated 5.0 out of 5 by 1.
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Alternativa namn: 1-(2-Amino-6-(2,6-dichlorophenyl)pyrido[2,3-d]pyrimidin-7-yl)-3-tert-butyl urea; PDGFR Tyrosine Kinase Inhibitor XIII
Ansökan EGF/FGF/PDGF receptor tyrosine kinase inhibitor is a tyrosine kinase inhibitor that inhibits human FGFR-1, PDGFR-β, c-Scr, & EGFR
Momsregistreringsnummer :: 1135256-66-4
Purity: ≥97%
Molecular Weight: 405.28
Molecular Formula: C18H18Cl2N6O
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data (including water content).

EGF/FGF/PDGF Receptor Tyrosine Kinase Inhibitor is a cell-permeable and reversible protein tyrosine kinase inhibitor that inhibits human Flg (FGFR-1), PDGFR-β, c-Scr, and EGFR, meanwhile exhibiting minimal activity against InsR, PKC, or CDK4/Cyclin D1. Inhibition by EGF/FGF/PDGF Receptor Tyrosine Kinase Inhibitor is shown to be noncompetitive in the case of c-Src, but ATP-competitive in the case of Flg (FGFR-1), PDGFR-β, and EGFR.


Konferenser

Hamby, J.M., et al. 1997. J. Med. Chem. 40, 2296. Dahring, T.K., et al. 1997. J. Pharmacol. Exp. Ther. 281, 1446.
S: 22-24/25-37-45

Physical State :
Solid
Solubility :
Soluble in DMSO (25 mg/ml), and ethanol (1 mg/ml).
LAGRING :
Store at 4° C
Melting Point :
256.77° C (Predicted)
Boiling Point :
594.56° C (Predicted)
Density :
~1.4 g/cm3 (Predicted)
Refractive Index :
n20D 1.69 (Predicted)
IC50 :
Flg: IC50 = 0.15 µM (human); PDGFR-β: IC50 = 0.18 µM (human); Platelet-derived growth factor receptor : IC50 = 0.63 µM (rat); c-Src: IC50 = 1.76 µM (human); EGFR: IC50 = 5.47 µM (human)
pK Values :
pKa: 9.85 (Predicted), pKb: 2.59 (Predicted)
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
PubChem CID :
5328112
SMILES :
CC(C)(C)NC(=O)NC1=C(C=C2C=NC(=NC2=N1)N)C3=C(C=CC=C3Cl)Cl

Download SDS (MSDS)

Certificate of Analysis

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EGF/FGF/PDGF receptor tyrosine kinase Inhibitor (CAS 1135256-66-4)  Produkt Citat

See how others have used EGF/FGF/PDGF receptor tyrosine kinase Inhibitor (CAS 1135256-66-4). Click on the entry to view the PubMed entry .

Citations 1 to 1 of 1 total

PMID: # 26107817  Valverde, A. et al. 2015. PloS one. 10: e0131363.

Citations 1 to 1 of 1 total
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