Anti-DRP1 Antibody (C-5) is a mouse monoclonal IgG1 κ DRP1 antibody, cited in 80 publications, provided at 200 µg/ml
raised against amino acids 560-736 mapping at the C-terminus of DRP1 of human origin
Anti-DRP1 Antibody (C-5) is recommended for detection of all DRP1 isoforms of mouse, rat and human origin by WB, IP, IF, IHC(P) and ELISA
Anti-DRP1 Antibody (C-5) is available conjugated to agarose for IP; HRP for WB, IHC(P) and ELISA; and to either phycoerythrin or FITC for IF, IHC(P) and FCM
also available conjugated to Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594 or Alexa Fluor® 647 for WB (RGB), IF, IHC(P) and FCM, and for use with RGB fluorescent imaging systems, such as iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
also available conjugated to Alexa Fluor® 680 or Alexa Fluor® 790 for WB (NIR), IF and FCM; for use with Near-Infrared (NIR) detection systems, such as LI-COR®Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
Contact our Technical Service Department (or your local Distributor) for more information on how to receive a FREE 10 µg sample of DRP1 (C-5): sc-271583.
m-IgG1 BP-HRP and m-IgGκ BP-HRP are the preferred secondary detection reagents for DRP1 Antibody (C-5) for WB and IHC(P) applications. These reagents are now offered in bundles with DRP1 Antibody (C-5) (see ordering information below).
Every item is shipped based on the best shipping method assessed for the temperature requirements of that specific item. Items are grouped and shipped together whenever
possible, and a separate shipping charge will be included for each shipping method required. Shipping charges listed below are from our US warehouses to the Contiguous US,
Alaska, Hawaii, Canada and Puerto Rico. Shipping charges for countries outside the US and Canada will be determined once order has been received
Please note: We can not ship to PO boxes
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Ships via FedEx Ground to Contiguous US, Alaska, Canada, Monday through Friday. This method is used for less temperature sensitive items such as lab ware and animal
health products, bulky and/or heavy items
Labware ships FedEx Ground free of charge to the contiguous US
DRP1 Antibody (C-5) is a high quality monoclonal DRP1 antibody (also designated DNM1L antibody or Dymple antibody) suitable for the detection of the DRP1 protein of mouse, rat and human origin. DRP1 Antibody (C-5) is available as both the non-conjugated anti-DRP1 antibody form, as well as multiple conjugated forms of anti-DRP1 antibody, including agarose, HRP, PE, FITC and multiple Alexa Fluor® conjugates. Dynamin-related protein 1 (DRP1) mediates outer mitochondrial membrane fission in mammalian cells. DRP1 is also known as Dynamin-like protein 1, (Dlp1), DVLP or Dymple. DRP1 contains the N-terminal tripartite GTP-binding domain characteristic of the Dynamin superfamily of GTPases. DRP1 exists as a T-shaped dimer which contains a head, leg and stalk. The addition of GTP induces a rearrangement of the head and stalk that generates a force that ultimately results in membrane constriction. DRP1 is ubiquitously expressed with abundant expression in skeletal muscle, heart, kidney and brain. In the cell, DRP1 localized to the perinuclear region. In mouse brain, DRP1 is highly expressed in the cerebellum with particularly high levels in cerebellar Purkinje cells. During apoptosis, DRP1 translocates from the cytosol to mitochondria and localizes to potential sites of organelle division. Cell death is averted upon DRP inhibition, suggesting a critical role for mitochondrial fission in apoptosis.
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
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