Anti-DPM1 Antibody (A-5) is a mouse monoclonal IgG1 κ DPM1 antibody, cited in 1 publications, provided at 200 µg/ml
specific for an epitope mapping between amino acids 78-102 within an internal region of DPM1 of human origin
Anti-DPM1 Antibody (A-5) is recommended for detection of DPM1 of mouse, rat and human origin by WB, IP, IF and ELISA
Anti-DPM1 Antibody (A-5) is available conjugated to agarose for IP; HRP for WB, IHC(P) and ELISA; and to either phycoerythrin or FITC for IF, IHC(P) and FCM
also available conjugated to Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594 or Alexa Fluor® 647 for WB (RGB), IF, IHC(P) and FCM, and for use with RGB fluorescent imaging systems, such as iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
also available conjugated to Alexa Fluor® 680 or Alexa Fluor® 790 for WB (NIR), IF and FCM; for use with Near-Infrared (NIR) detection systems, such as LI-COR®Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
Contact our Technical Service Department (or your local Distributor) for more information on how to receive a FREE 10 µg sample of DPM1 (A-5): sc-515721.
m-IgGκ BP-HRP (mouse IgGκ binding protein-HRP) is the preferred detection reagent for DPM1 Antibody (A-5) for WB applications. This reagent is now offered in a bundle with DPM1 Antibody (A-5) (see ordering information below). For additional m-IgGκ BP conjugates see our complete list of Mouse IgG Binding Proteins.
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Alaska, Hawaii, Canada and Puerto Rico. Shipping charges for countries outside the US and Canada will be determined once order has been received
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Ships via FedEx Ground to Contiguous US, Alaska, Canada, Monday through Friday. This method is used for less temperature sensitive items such as lab ware and animal
health products, bulky and/or heavy items
Labware ships FedEx Ground free of charge to the contiguous US
DPM1 Antibody (A-5) is a high quality monoclonal DPM1 antibody (also designated DPM1 antibody) suitable for the detection of the DPM1 protein of mouse, rat and human origin. DPM1 Antibody (A-5) is available as both the non-conjugated anti-DPM1 antibody form, as well as multiple conjugated forms of anti-DPM1 antibody, including agarose, HRP, PE, FITC and multiple Alexa Fluor® conjugates. Biosynthesis of glycosylphosphatidylinositol and N-glycan pre-cursor is dependent upon a mannosyl donor, dolichol phosphate-mannose (DPM). DPM synthase, a transmembrane protein, is associated with membranes of the rough endoplasmic reticulum and catalyzes mannosyl transfer from GDP-mannose hydrophobic long-chain acceptor dolichyl-phosphate (3-4). DPM synthase in various organisms are grouped into two types. One type is a single-component enzyme, represented by Saccharomyces cerevisiae, and the other is a multicomponent enzyme which is represented by human DPM synthase and consists of three subunits: DPM1, DPM2 and DPM3. DPM1 is not sufficient for DPM synthesis, which requires the 84 amino acid DPM2 protein for localization to the ER and stable expression of DPM1. The third subunit, DPM3, comprises 92 amino acids, and it is associated with DPM1 via its C-terminal domain and with DPM2 via its N-terminal region. The stability of DPM1 is directly dependent upon DPM3, which is stablized by DPM2. DPM synthase activity is associated with an ER phosphoprotein. In addition, a mitochondrial DPM synthase exists, which is located on the cytosolic face of the outer membrane of mitochondria.
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
To place an order using RMB or to ship to mainland China, please visit www.scbio.cn