DNA-PK Inhibitor V (CAS 404009-46-7)

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Ansökan DNA-PK Inhibitor V is a morpholino-benzophenone ATP-competitive inhibitor

CAS Nr: 404009-46-7

Molekylvikt: 283.3

Molekylär formel: C₁₇H₁₇NO₃

For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.

* Refer to Certificate of Analysis for lot specific data (including water content).

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SDS & Certificate of Analysis

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DNA-PK Inhibitor V is a morpholino-benzophenone compound. Potent, selective and ATP-competitive inhibitor of DNA-PK (IC₅₀ = 270 nM). Inhibits PI 3-K catalytic subunit p110-isozymes at higher concentrations (IC₅₀ = 32 μM, 3.7 μM, 22 μM and ~ 100μM for α, β, δ and γ, respectively) and weakly inhibits a panel of several other kinases, including, ATM, ATR, CK2, GRK2, mTOR, PI 3KC2α, PI 3KC2β, PI 3KC2γ and PI 4Kβ, even at concentrations as high as 50μM.

Konferenser

Knight, Z.A., et al. 2004. Bioorg. Med. Chem. 12, 4749. Willmore, E., et al. 2004. Blood,103, 4659.

Physical State :

Solid

Solubility :

Soluble in DMSO.

LAGRING :

Store at 4° C

IC50 :

DNA-PK: IC₅₀ = 270 nM; PI 3-K catalytic subunit p110-isozyme α: IC₅₀ = 32 µM; PI 3-K catalytic subunit p110-isozyme β: IC₅₀ = 3.7 µM; PI 3-K catalytic subunit p110-isozyme δ: IC₅₀ = 22 µM; PI 3-K catalytic subunit p110-isozyme γ: IC₅₀ = ~ 100 µM

For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.

PubChem CID :

16760391

SMILES :

C1COCCN1C2=CC(=C(C=C2)C(=O)C3=CC=CC=C3)O

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Certificate of Analysis

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