DNA-PK Inhibitor II (CAS 154447-35-5)

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See product citations (6)

Alternativa namn: NU7026; 2-(Morpholin-4-yl)-benzo[h]chromen-4-one

Ansökan DNA-PK Inhibitor II is an antiproliferative agent, and inhibitor of DNA-PK

CAS Nr: 154447-35-5

Renhet: >98%

Molekylvikt: 281.31

Molekylär formel: C₁₇H₁₅NO₃

For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.

* Refer to Certificate of Analysis for lot specific data (including water content).

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DNA-PK inhibitor II, a cell-permeable compound, is shown to be a potent inhibitor of DNA repair enzymes. DNA-PK inhibition makes it potentially possible to make cell lines become more sensitive to ionizing radiation (IR) and a reduction of lethal damage recovery could be possible. DNA-PK inhibitor II treatment of cells is shown to inhibit IR-induced DNA double strand break repair.

Konferenser

1. Vlahos, C.J., et al. 1994. J. Biol. Chem. 269: 5241-5248. PMID: 8106507
2. Hollick, J.J., et al. 2003. Bioorg. Med. Chem. Lett. 13: 3083-3086. PMID: 12941339
3. Veuger, S.J., et al. 2003. Cancer Res. 63: 6008-6015. PMID: 14522929
4. Willmore, E., et al. 2004. Blood. 103: 4659-4665. PMID: 15010369

Physical State :

Solid

Solubility :

Soluble in DMSO (3 mg/ml) at 60° C, methanol (700 µg/ml), DMF (~0.15 mg/ml), and DMSO (10 mM). Insoluble in water.

LAGRING :

Store at 4° C

Melting Point :

175.74° C (Predicted)

Boiling Point :

459.88° C at 760 mmHg (Predicted)

Density :

1.33 g/cm³ (Predicted)

Refractive Index :

n²⁰_D 1.67 (Predicted)

IC50 :

DNA-PK: IC₅₀ = 0.23 µM; PI 3-K: IC₅₀ = 13 µM; ATM: IC₅₀ = >100 µM; ATR: IC₅₀ = >100 µM

pK Values :

pK_b: 0.49 (Predicted)

For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.

WGK Germany :

PubChem CID :

9860529

MDL Number :

MFCD06798345

SMILES :

O=c1cc(oc2c1ccc1ccccc21)N1CCOCC1

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Certificate of Analysis

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DNA-PK Inhibitor II (CAS 154447-35-5) Produkt Citat

See how others have used DNA-PK Inhibitor II (CAS 154447-35-5). Click on the entry to view the PubMed entry .

Citations 1 to 6 of 6 total

PMID: # 27129079 Boichuk, S. et al. 2016. Anticancer Drugs. 27: 620-34.

PMID: # 23939025 2013. Mol. Ther. 21: 2205-16.

PMID: # 15010369 Willmore, E. et al. 2004. Blood. 103: 4659-4665.

PMID: # 14522929 Veuger, SJ. et al. 2003. Cancer Res. 63: 6008-6015.

PMID: # 32194286 Biol Blood Marrow Transplant. 1273-1279.

PMID: # 29511342 Cell Death Differ. 1967-1979.

Citations 1 to 6 of 6 total

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