DMNB (4,5-dimethoxy-2-nitrobenzaldehyde) is a cell-permeable vanillin derivative and potent inhibitor of DNA-PK (IC50 = 15 μM). DMNB is shown in experiments to increase DR4/DR5 mRNA levels and their surface expression and decrease c-FLIP mRNA levels in K56. DMNB is also an enzyme involved in the non-homologous end-joining (NHEJ) pathway of double-stranded DNA break (DSB) repair.
1. Durant, S., et al. 2003. Nucleic Acids Res. 31: 5501-5512. PMID: 14500812
2. Kim, M.J., et al. 2009. Biochem. Pharmacol. 78: 573-582. PMID: 19464267
See how others have used DMNB (CAS 20357-25-9). Click on the entry to view the PubMed entry .
PMID: # 23373904 Shepelev, MV. et al. 2013. Mol. Pharm. 10: 931-9.
PMID: # 19464267 Kim, MJ. et al. 2009. Biochem. Pharmacol. 78: 573-582.
Santa Cruz Biotechnology, Inc. is a world leader in the development of products for the biomedical research market. Call us Toll Free at 1-800-457-3801.
Copyright © 2007-2021 Santa Cruz Biotechnology, Inc. All Rights Reserved. "Santa Cruz Biotechnology", and the Santa Cruz Biotechnology, Inc. logo, "Santa Cruz Animal Health", "San Juan Ranch", "Supplement of Champions", the San Juan Ranch logo, "Ultracruz", "Chemcruz", "Immunocruz", "Exactacruz", and "EZ Touch" are registered trademarks of Santa Cruz Biotechnology, Inc.
All trademarks are the property of their respective owners.