DMNB CAS: 20357-25-9
MF: C9H9NO5
MW: 211.2
A vanillin derivative and potent inhibitor of DNA-PK.

DMNB (CAS 20357-25-9)

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Alternativa namn: 6-Nitroveratraldehyde
Ansökan DMNB is a vanillin derivative and potent inhibitor of DNA-PK
CAS Nr: 20357-25-9
Renhet: ≥90%
Molekylvikt: 211.2
Molekylär formel: C9H9NO5
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data (including water content).

DMNB (4,5-dimethoxy-2-nitrobenzaldehyde) is a cell-permeable vanillin derivative and potent inhibitor of DNA-PK (IC50 = 15 μM). DMNB is shown in experiments to increase DR4/DR5 mRNA levels and their surface expression and decrease c-FLIP mRNA levels in K56. DMNB is also an enzyme involved in the non-homologous end-joining (NHEJ) pathway of double-stranded DNA break (DSB) repair.


Konferenser

1. Durant, S., et al. 2003. Nucleic Acids Res. 31: 5501-5512. PMID: 14500812
2. Kim, M.J., et al. 2009. Biochem. Pharmacol. 78: 573-582. PMID: 19464267

Physical State :
Solid
Solubility :
Soluble in water (partly), DMSO (5 mg/ml), and ethanol (25 mM).
LAGRING :
Store at 4° C
Melting Point :
131-133° C (lit.)
Boiling Point :
390.77° C at 760 mmHg (Predicted)
Density :
1.31 g/cm3 (Predicted)
Refractive Index :
n20D 1.57 (Predicted)
IC50 :
DNA-PK: IC50 = 15 µM
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
WGK Germany :
3
PubChem CID :
MDL Number :
MFCD00007134
EC Number :
243-762-1
Beilstein Registry :
395599
SMILES :
COC1=C(C=C(C(=C1)C=O)[N+](=O)[O-])OC

Download SDS (MSDS)

Certificate of Analysis

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DMNB (CAS 20357-25-9)  Produkt Citat

See how others have used DMNB (CAS 20357-25-9). Click on the entry to view the PubMed entry .

Citations 1 to 2 of 2 total

PMID: # 23373904  Shepelev, MV. et al. 2013. Mol. Pharm. 10: 931-9.

PMID: # 19464267  Kim, MJ. et al. 2009. Biochem. Pharmacol. 78: 573-582.

Citations 1 to 2 of 2 total
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