Dehydrocostus Lactone CAS: 477-43-0
MF: C15H18O2
MW: 230.3
Inhibitor of NF kappa B activation via disruption of TNF alpha processes.

Dehydrocostus Lactone (CAS 477-43-0)

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Alternativa namn: Dehydrocostuslactone; (3as,6ar,9ar,9bs)-3,6,9-trimethylidenedecahydroazuleno[4,5-b]furan-2(3h)-one
Ansökan Dehydrocostus Lactone is inhibitor of NF kappa B activation via disruption of TNF alpha processes
CAS Nr: 477-43-0
Molekylvikt: 230.3
Molekylär formel: C15H18O2
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data (including water content).

Dehydrocostus Lactone inhibits NF kappa B activiation by preventing TNF α induced degradation and phosphorylation. Dehydrocostus Lactoner renders HL-60 cells susceptible to TNF α induced apoptosis by enhancing caspase3 and caspase8 activities.


Konferenser

1. Loizzo, M.R., et al. 2007. Anticancer Res. 27: 3293-3299. PMID: 17970073
2. Jeong, G.S., et al. 2007. Eur J Pharmacology 565: 37-44. PMID: 17391667

Physical State :
Solid
Solubility :
Soluble in DMSO (≥20 mg/ml).
LAGRING :
Store at -20° C
Melting Point :
99.20° C (Predicted)
Boiling Point :
383.71° C at 760 mmHg (Predicted)
Density :
1.09 g/cm3 (Predicted)
Refractive Index :
n20D 1.54 (Predicted)
IC50 :
HL-60: IC50 = 5.3 µM (human); A549: IC50 = 10 µM (human)
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
WGK Germany :
3
PubChem CID :
MDL Number :
MFCD00210277
SMILES :
C=C1CCC2C(C3C1CCC3=C)OC(=O)C2=C

Download SDS (MSDS)

Certificate of Analysis

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