D-myo-Inositol-1,4,5,6-tetraphosphate, sodium salt is one of several different inositol oligophosphate isomers implicated in signal transduction. Production of Ins(1,4,5,6)P4 by intestinal epithelial cells increases approximately 2-14 fold, following infection with Salmonella. Ins(1,4,5,6)P4 antagonizes epidermal growth factor (EGF) signalling through the phosphatidylinositol 3-kinase pathway. Ins(1,4,5,6)P3 is less potent than Ins(1,4,5)P3 at initiating Ca2+ release when injected into Xenopus oocytes.
1 Eckmann, L., Rudolf, M.T., Ptasznik, A., et al. D-myo-Inositol 1,4,5,6-tetrakisphosphate produced in human intestinal epithelial cells in response to salmonella invasion inhibits phosphoinositide 3-kinase signaling pathways. Proc Natl Acad Sci USA 94 14456-14460 (1997). 2 DeLisle, S., Radenberg, T., Wintermantel, M.R., et al. Second messenger specificity of the inositol trisphosphate receptor: Reappraisal based on novel inositol phosphates. Am J Physiol Cell Physiol 35 C429-C436 (1994).
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