D-myo-Inositol-1,2,3,4-tetraphosphate, sodium salt is one of the many inositol phosphate (InsP) isomers that could act as small, soluble second messengers in the transmission of cellular signals.1,2,3 Ins(1,2,3,4)-P4 displays agonist activity at the Ins(1,4,5)-P3 receptor expressed in CHO cells where it induces Ca2+ mobilization with an ED50 value of 18.1 μM, making it nearly 180-fold less effective than Ins(1,4,5)-P3 in the same assay.
1 Berridge, M.J. Inositol trisphosphate and calcium signalling. Nature 361 315-325 (1993). 2 Majerus, P.W. Inositol phosphate biochemistry. Annu Rev Biochem 61 225-250 (1992). 3 Shears, S.B. The versatility of inositol phosphates as cellular signals. Biochim Biophys Acta 1436 49-67 (1998). 4 Burford, N.T., Nahorski, S.R., Chung, S., et al. Binding and activity of the nine possible regioisomers of myo-inositol tetrakisphosphate at the inositol 1,4,5-trisphosphate receptor. Cell Calcium 21 301-310 (1997).
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