Anti-CyPA Antibody (6-YD13) is a mouse monoclonal IgG2a κ CyPA antibody, cited in 10 publications, provided at 100 µg/ml
raised against full length CyPA of human origin
recommended for detection of CyPA of mouse, rat and human origin by WB, IP and ELISA
Contact our Technical Service Department (or your local Distributor) for more information on how to receive a FREE 10 µg sample of CyPA (6-YD13): sc-134310.
m-IgG Fc BP-HRP and m-IgG2a BP-HRP are the preferred secondary detection reagents for CyPA Antibody (6-YD13) for WB applications. These reagents are now offered in bundles with CyPA Antibody (6-YD13) (see ordering information below).
Every item is shipped based on the best shipping method assessed for the temperature requirements of that specific item. Items are grouped and shipped together whenever
possible, and a separate shipping charge will be included for each shipping method required. Shipping charges listed below are from our US warehouses to the Contiguous US,
Alaska, Hawaii, Canada and Puerto Rico. Shipping charges for countries outside the US and Canada will be determined once order has been received
Please note: We can not ship to PO boxes
Express Blue Ice
Express Dry Ice
Animal Health Prescription Item
SHIPPING METHODS & CHARGES
Ships via FedEx Ground to Contiguous US, Alaska, Canada, Monday through Friday. This method is used for less temperature sensitive items such as lab ware and animal
health products, bulky and/or heavy items
Labware ships FedEx Ground free of charge to the contiguous US
CyPA Antibody (6-YD13) is a high quality monoclonal CyPA antibody (also designated PPIA antibody, Peptidyl-Prolyl Cis-Trans Isomerase A antibody, Cyclosporin A-Binding Protein antibody, Cyclophilin A antibody, Rotamase A antibody, PPIase A antibody, Peptidylprolyl Isomerase A (Cyclophilin A) antibody, T Cell Cyclophilin antibody, or CYPH antibody) suitable for the detection of the CyPA protein of mouse, rat and human origin. CyPA Antibody (6-YD13) is available as the non-conjugated anti-CyPA antibody. The immunosuppressant cyclosporin A (CsA) forms a trimolecular complex with cyclophilin and calcineurins to inhibit calcineurin phosphatase activity. Cyclophilins are conserved, ubiquitous and abundant cytosolic peptidyl-prolyl cis-trans isomerases that accelerate the isomerization of XaaPro peptide bonds and the refolding of proteins. Human cyclophilin A (CyPA), an intracellular protein of 165 amino acids, is the target of the CsA and is encoded by a single unique gene conserved from yeast to humans. CyPA is known for its involvement in T cell differentiation and proliferation and is highly expressed in brain. CyPA is incorporated into the virion of the type 1 human immunodeficiency virus (HIV-1) via a direct interaction with the capsid domain of the viral Gag polyprotein and is crucial for efficient viral replication. Cyclophilin B (CyPB) is a member of the cyclophilin family with specific N- and C-terminal extensions. Unlike CyPA, CyPB has a signal sequence leading to its translocation in the endoplasmic reticulum. CyPB is secreted in biological fluids such as blood or milk and binds to a specific receptor present on the human lymphoblastic cell line Jurkat and on human peripheral blood lymphocytes (9,10).
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.