cyclin T1 Antibody (E-6) is a mouse monoclonal IgG2b (kappa light chain) provided at 200 µg/ml
raised against amino acids 261-505 mapping within an internal region of cyclin T1 of human origin
recommended for detection of cyclin T1 of mouse, rat and human origin by WB, IP, IF and ELISA
TransCruz reagent for ChIP application (sc-271576 X, 200 µg/0.1 ml)
See cyclin T1 (E-3): sc-271348 for cyclin T1 antibody conjugates, including AC, HRP, FITC, PE, Alexa Fluor® 488, 594, 647, 680 and 790.
m-IgG2b BP-HRP and m-IgGκ BP-HRP are the preferred secondary detection reagents for cyclin T1 Antibody (E-6) for WB applications. These reagents are now offered in bundles with cyclin T1 Antibody (E-6) (see ordering information below).
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possible, and a separate shipping charge will be included for each shipping method required. Shipping charges listed below are from our US warehouses to the Contiguous US,
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SHIPPING METHODS & CHARGES
Ships via FedEx Ground to Contiguous US, Alaska, Canada, Monday through Friday. This method is used for less temperature sensitive items such as lab ware and animal
health products, bulky and/or heavy items
Labware ships FedEx Ground free of charge to the contiguous US
Cyclin T1 was identified as a partner for Cdk9, an RNA polymerase II (RNAPII) transcription elongation factor. Cyclin T1 interacts with the transactivation domain of the HIV-1 Tat protein. The interaction of Tat with cyclin T1 enhances the affinity of Tat for the viral TAR RNA stem-loop structure, suggesting that Tat can recruit cyclin T1/cdk9 to RNAPII through cooperative binding to TAR. The human positive transcription elongation factor b (P-TEFb) consists of a cyclin dependent kinase, cdk9, paired with a cyclin T. Cdk9 may be paired with either cyclin T1 or cyclin T2, in a mutually exclusive manner. Two forms of cyclin T2, T2a and T2b, are due to alternative splicing. The binding of Tat to TAR was shown to be facilitated by human cyclin T1, but not by cyclins T2a or T2b. Cyclin T2 binds to Cdk9 but not to Tat, and cyclin T2 can inhibit cyclin T1-mediated Tat activity.
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
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