Anti-cyclin B1 Antibody (GNS1) is a mouse monoclonal IgG1 κ cyclin B1 antibody, cited in 1,116 publications, provided at 200 µg/ml
raised against a recombinant protein corresponding to human cyclin B1
Anti-cyclin B1 Antibody (GNS1) is recommended for detection of cyclin B1 of mouse, rat and human origin by WB, IP, IF and IHC(P)
Anti-cyclin B1 Antibody (GNS1) is available conjugated to agarose for IP; HRP for WB, IHC(P) and ELISA; and to either phycoerythrin or FITC for IF, IHC(P) and FCM
also available conjugated to Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594 or Alexa Fluor® 647 for WB (RGB), IF, IHC(P) and FCM, and for use with RGB fluorescent imaging systems, such as iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
also available conjugated to Alexa Fluor® 680 or Alexa Fluor® 790 for WB (NIR), IF and FCM; for use with Near-Infrared (NIR) detection systems, such as LI-COR®Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
also available conjugated to either TRITC or Alexa Fluor® 405 for IF, IHC(P) and FCM
TransCruz reagent for ChIP application (sc-245 X, 200 µg/0.1 ml)
Contact our Technical Service Department (or your local Distributor) for more information on how to receive a FREE 10 µg sample of cyclin B1 (GNS1): sc-245.
m-IgG Fc BP-HRP, m-IgG1 BP-HRP and m-IgGκ BP-HRP are the preferred secondary detection reagents for cyclin B1 Antibody (GNS1) for WB and IHC(P) applications. These reagents are now offered in bundles with cyclin B1 Antibody (GNS1) (see ordering information below).
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Labware ships FedEx Ground free of charge to the contiguous US
cyclin B1 Antibody (GNS1) is a high quality monoclonal cyclin B1 antibody (also designated CCNB1 antibody) suitable for the detection of the cyclin B1 protein of mouse, rat and human origin. cyclin B1 Antibody (GNS1) is available as both the non-conjugated anti-cyclin B1 antibody form, as well as multiple conjugated forms of anti-cyclin B1 antibody, including agarose, HRP, PE, FITC and multiple Alexa Fluor® conjugates. In eukaryotic cells, mitosis is initiated following the activation of a protein kinase known variously as maturation-promoting factor, M-phase specific histone kinase or M-phase kinase. This protein kinase is composed of a catalytic subunit (Cdc2), a regulatory subunit (cyclin B) and a low molecular weight subunit (p13-Suc 1). The Cdc/cyclin enzyme is subject to multiple levels of control, of which the regulation of the catalytic subunit by tyrosine phosphorylation is the best understood. Tyrosine phosphorylation inhibits the Cdc2/cyclin B enzyme; tyrosine dephosphorylation, occurring at the onset of mitosis, directly activates the pre-MPF complex. Evidence has established that B type cyclins not only act on M-phase regulatory subunits of the Cdc2 protein kinase, but also activate the Cdc25A and Cdc25B endogenous tyrosine phosphatase, of which Cdc2 is the physiological substrate. The specificity of this effect is shown by the inability of either cyclin A or cyclin D1 to display any such stimulation of Cdc25A or Cdc25B.
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
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To place an order using RMB or to ship to mainland China, please visit www.scbio.cn