Anti-CUL-7 Antibody (AB38) is a mouse monoclonal IgG2b κ CUL-7 antibody, cited in 2 publications, provided at 200 µg/ml
Anti-CUL-7 Antibody (AB38) is recommended for detection of CUL-7 and PARC of mouse, rat and human origin by WB, IP, IF and IHC(P)
Anti-CUL-7 Antibody (AB38) is available conjugated to agarose for IP; HRP for WB, IHC(P) and ELISA; and to either phycoerythrin or FITC for IF, IHC(P) and FCM
also available conjugated to Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594 or Alexa Fluor® 647 for WB (RGB), IF, IHC(P) and FCM, and for use with RGB fluorescent imaging systems, such as iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
also available conjugated to Alexa Fluor® 680 or Alexa Fluor® 790 for WB (NIR), IF and FCM; for use with Near-Infrared (NIR) detection systems, such as LI-COR®Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
Contact our Technical Service Department (or your local Distributor) for more information on how to receive a FREE 10 µg sample of CUL-7 (AB38): sc-53810.
m-IgG Fc BP-HRP is the preferred secondary detection reagent for CUL-7 Antibody (AB38) for WB and IHC(P) applications. This reagent is now offered in a bundle with CUL-7 Antibody (AB38) (see ordering information below).
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CUL-7 Antibody (AB38) is a high quality monoclonal CUL-7 antibody (also designated Cullin 7 antibody or CUL7 antibody) suitable for the detection of the CUL-7 protein of mouse, rat and human origin. CUL-7 Antibody (AB38) is available as both the non-conjugated anti-CUL-7 antibody form, as well as multiple conjugated forms of anti-CUL-7 antibody, including agarose, HRP, PE, FITC and multiple Alexa Fluor® conjugates. Cullin proteins comprise a distinct family of mediators that participate in the selective targeting of proteins for ubiquitin (Ub)-mediated proteolysis. CUL-7 mediates the third step of ubiquitin conjugation as part of an SCF-like complex consisting of CUL-7, RBX1, SKP1, FBXW8 and GLMN isoform 1, which interacts with a complex of SKP1 and FBXW8, but not with SKP1 alone. This complex is thought to play a role in the degradation of proteins involved in proliferation and/or differentiation. CUL-7 is highly expressed in fetal kidney and adult skeletal muscle in addition to abundant expression in fetal brain, and adult pancreas, kidney, placenta and heart. It is also detected in trophoblasts, lymphoblasts, osteoblasts, chondrocytes and skin fibroblasts. Defects in the gene encoding CUL-7 result in 3-M syndrome, an autosomal recessive disorder characterized by severe pre- and postnatal growth retardation, facial dysmorphism, large head circumference and skeletal changes, including long slender tubular bones and tall vertebral bodies.
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
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