Chenodeoxycholic acid, free acid CAS: 474-25-9
MF: C24H40O4
MW: 392.57
An apoptosis inducer via PKC-dependent signalling pathway.

Chenodeoxycholic acid, free acid (CAS 474-25-9)

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Alternativa namn: Chenodeoxycholate; Chenodiol; CDC
Ansökan Chenodeoxycholic acid, free acid is an apoptosis inducer via PKC-dependent signalling pathway
CAS Nr: 474-25-9
Renhet: ≥95%
Molekylvikt: 392.57
Molekylär formel: C24H40O4
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data (including water content).

Chenodeoxycholic Acid, Free Acid and its 7β-isomer ursodeoxycholic acid (sc-204935), are potent (nanomolar affinity) selective inhibitors of DD2 (AKR1C2). These compounds were non-competitive inhibitors of AKR1D1 yielding Ki values of 3.2 μM for chenodeoxycholic acid. This chemical is a hydrophobic primary bile acid, which increases intracellular Ca2+ in rat hepatocyte couplets. Studies indicate that Chenodeoxycholic Acid induces apoptosis through a PKC dependent pathway. It is known that Chenodeoxycholic Acid is essential in the metabolism of cholesterol via activation of nuclear receptors. This bile acid can also bind to BABP with a stoichiometery of 1:2. Alternate studies indicate that chenodeoxycholic acid can inhibit the expression of IL-6 and cell viability in QBC939 cells.


Konferenser

1. McNeilly, A.D., et al. 2010. J. Hepatol. 52: 705-711. PMID: 20347173
2. Wang, J., et al. 2010. Zhonghua Wai Ke Za Zhi. 48(: 919-923. PMID: 21055228

Physical State :
Solid
Solubility :
Soluble in ethanol (~20 mg/ml), methanol, acetone, glacial acetic acid, DMF, DMSO, and 1:1 DMF:PBS(pH 7.2) (~0.5 mg/ml). Insoluble in water.
LAGRING :
Store at -20° C
Melting Point :
165-167° C (lit.)
Boiling Point :
547.15° C at 760 mmHg (Predicted)
Density :
1.1 g/cm3 (Predicted)
Refractive Index :
n20D 1.54 (Predicted)
Optical Activity :
α20/D +12°, c = 2 in ethanol
IC50 :
GBM: IC50 = >5000 nM (Homo sapiens); HCT-116 (Colon carcinoma cells): IC50 = >5000 nM (Homo sapiens); Bile acid receptor FXR: EC5050 = 3400 nM (Homo sapiens)
pK Values :
pKa: 4.76
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
WGK Germany :
3
RTECS :
FZ1980000
PubChem CID :
Merck Index :
14: 2054
MDL Number :
MFCD00064142
EC Number :
207-481-8
Beilstein Registry :
3219887
SMILES :
CC(CCC(=O)O)C1CCC2C1(CCC3C2C(CC4C3(CCC(C4)O)C)O)C

Download SDS (MSDS)

Certificate of Analysis

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