Chenodeoxycholic acid, free acid (CAS 474-25-9)

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Alternativa namn: Chenodeoxycholate; Chenodiol; CDC

Ansökan Chenodeoxycholic acid, free acid is an apoptosis inducer via PKC-dependent signalling pathway

CAS Nr: 474-25-9

Renhet: ≥95%

Molekylvikt: 392.57

Molekylär formel: C₂₄H₄₀O₄

For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.

* Refer to Certificate of Analysis for lot specific data (including water content).

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SDS & Certificate of Analysis

Chenodeoxycholic acid, free acid: sc-278835...

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Chenodeoxycholic Acid, Free Acid and its 7β-isomer ursodeoxycholic acid (sc-204935), are potent (nanomolar affinity) selective inhibitors of DD2 (AKR1C2). These compounds were non-competitive inhibitors of AKR1D1 yielding K_i values of 3.2 μM for chenodeoxycholic acid. This chemical is a hydrophobic primary bile acid, which increases intracellular Ca²⁺ in rat hepatocyte couplets. Studies indicate that Chenodeoxycholic Acid induces apoptosis through a PKC dependent pathway. It is known that Chenodeoxycholic Acid is essential in the metabolism of cholesterol via activation of nuclear receptors. This bile acid can also bind to BABP with a stoichiometery of 1:2. Alternate studies indicate that chenodeoxycholic acid can inhibit the expression of IL-6 and cell viability in QBC939 cells.

Konferenser

1. McNeilly, A.D., et al. 2010. J. Hepatol. 52: 705-711. PMID: 20347173
2. Wang, J., et al. 2010. Zhonghua Wai Ke Za Zhi. 48(: 919-923. PMID: 21055228

Physical State :

Solid

Solubility :

Soluble in ethanol (~20 mg/ml), methanol, acetone, glacial acetic acid, DMF, DMSO, and 1:1 DMF:PBS(pH 7.2) (~0.5 mg/ml). Insoluble in water.

LAGRING :

Store at -20° C

Melting Point :

165-167° C (lit.)

Boiling Point :

547.15° C at 760 mmHg (Predicted)

Density :

1.1 g/cm³ (Predicted)

Refractive Index :

n²⁰_D 1.54 (Predicted)

Optical Activity :

α20/D +12°, c = 2 in ethanol

IC50 :

GBM: IC₅₀ = >5000 nM (Homo sapiens); HCT-116 (Colon carcinoma cells): IC₅₀ = >5000 nM (Homo sapiens); Bile acid receptor FXR: EC₅₀50 = 3400 nM (Homo sapiens)

pK Values :

pK_a: 4.76

For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.

WGK Germany :

3

RTECS :

FZ1980000

PubChem CID :

10133

Merck Index :

14: 2054

MDL Number :

MFCD00064142

EC Number :

207-481-8

Beilstein Registry :

3219887

SMILES :

CC(CCC(=O)O)C1CCC2C1(CCC3C2C(CC4C3(CCC(C4)O)C)O)C

Download SDS (MSDS)

Certificate of Analysis

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