Anti-Cdt2 Antibody (B-8) is a mouse monoclonal IgG1 κ Cdt2 antibody, cited in 1 publications, provided at 200 µg/ml
raised against amino acids 1-240 mapping at the N-terminus of Cdt2 of human origin
Cdt2 Antibody (B-8) is recommended for detection of Cdt2 of human origin by WB, IP, IF and ELISA
Anti-Cdt2 Antibody (B-8) is available conjugated to agarose for IP; HRP for WB, IHC(P) and ELISA; and to either phycoerythrin or FITC for IF, IHC(P) and FCM
also available conjugated to Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594 or Alexa Fluor® 647 for WB (RGB), IF, IHC(P) and FCM, and for use with RGB fluorescent imaging systems, such as iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
also available conjugated to Alexa Fluor® 680 or Alexa Fluor® 790 for WB (NIR), IF and FCM; for use with Near-Infrared (NIR) detection systems, such as LI-COR®Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
Contact our Technical Service Department (or your local Distributor) for more information on how to receive a FREE 10 µg sample of Cdt2 (B-8): sc-166735.
m-IgG Fc BP-HRP and m-IgG1 BP-HRP are the preferred secondary detection reagents for Cdt2 Antibody (B-8) for WB applications. These reagents are now offered in bundles with Cdt2 Antibody (B-8) (see ordering information below).
Every item is shipped based on the best shipping method assessed for the temperature requirements of that specific item. Items are grouped and shipped together whenever
possible, and a separate shipping charge will be included for each shipping method required. Shipping charges listed below are from our US warehouses to the Contiguous US,
Alaska, Hawaii, Canada and Puerto Rico. Shipping charges for countries outside the US and Canada will be determined once order has been received
Please note: We can not ship to PO boxes
Express Blue Ice
Express Dry Ice
Animal Health Prescription Item
SHIPPING METHODS & CHARGES
Ships via FedEx Ground to Contiguous US, Alaska, Canada, Monday through Friday. This method is used for less temperature sensitive items such as lab ware and animal
health products, bulky and/or heavy items
Labware ships FedEx Ground free of charge to the contiguous US
Cdt2 Antibody (B-8) is a high quality monoclonal Cdt2 antibody (also designated DTL antibody or RAMP antibody) suitable for the detection of the Cdt2 protein of human origin. Cdt2 Antibody (B-8) is available as both the non-conjugated anti-Cdt2 antibody form, as well as multiple conjugated forms of anti-Cdt2 antibody, including agarose, HRP, PE, FITC and multiple Alexa Fluor® conjugates. WD-repeats are motifs that are found in a variety of proteins and are characterized by a conserved core of 40-60 amino acids that commonly form a tertiary propeller structure. While proteins that contain WD-repeats participate in a wide range of cellular functions, they are generally involved in regulatory mechanisms concerning chromatin assembly, cell cycle control, signal transduction, RNA processing, apoptosis and vesicular trafficking. Cdt2, also known as DTL (denticleless homolog), CDW1, DCAF2, L2DTL or RAMP, is a 730 amino acid protein that localizes to both the cytoplasm and the nuclear membrane and contains seven WD repeats. Expressed in testis, placenta, bone marrow, thymus and skeletal muscle, Cdt2 is required for DNA damage-induced Cdt1 proteolysis and is also thought to play an essential role in DNA replication and cell proliferation. Upon DNA damage, Cdt2 is subject to phosphorylation, probably by ATM or ATR. Two isoforms of Cdt2 exist due to alternative splicing events.
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences