Anti-CBP/KAT3A/CREBBP Antibody (C-1) is a mouse monoclonal IgG1 κ CBP/KAT3A/CREBBP antibody, cited in 120 publications, provided at 200 µg/ml
specific for an epitope mapping between amino acids 2423-2442 at the C-terminus of CBP of human origin (identical to corresponding mouse sequence)
CBP/KAT3A/CREBBP Antibody (C-1) is recommended for detection of CBP p265 of mouse, rat, human and origin by WB, IP, IF, IHC(P) and ELISA; also reactive with additional species, including and canine, bovine, porcine and avian
Anti-CBP/KAT3A/CREBBP Antibody (C-1) is available conjugated to agarose for IP; HRP for WB, IHC(P) and ELISA; and to either phycoerythrin or FITC for IF, IHC(P) and FCM
also available conjugated to Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594 or Alexa Fluor® 647 for WB (RGB), IF, IHC(P) and FCM, and for use with RGB fluorescent imaging systems, such as iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
also available conjugated to Alexa Fluor® 680 or Alexa Fluor® 790 for WB (NIR), IF and FCM; for use with Near-Infrared (NIR) detection systems, such as LI-COR®Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
TransCruz reagent for Gel Supershift and ChIP applications (sc-7300 X, 200 µg/0.1 ml)
Contact our Technical Service Department (or your local Distributor) for more information on how to receive a FREE 10 µg sample of CBP/KAT3A/CREBBP (C-1): sc-7300.
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Ships via FedEx Ground to Contiguous US, Alaska, Canada, Monday through Friday. This method is used for less temperature sensitive items such as lab ware and animal
health products, bulky and/or heavy items
Labware ships FedEx Ground free of charge to the contiguous US
CBP Antibody (C-1) is a high quality monoclonal CBP antibody (also designated CREBBP antibody or KAT3A antibody) suitable for the detection of the CBP protein of mouse, rat and human origin. CBP Antibody (C-1) is available as both the non-conjugated anti-CBP antibody form, as well as multiple conjugated forms of anti-CBP antibody, including agarose, HRP, PE, FITC and multiple Alexa Fluor® conjugates. Cyclic AMP-regulated gene expression frequently involves a DNA element designated the cAMP-regulated enhancer (CRE). Many transcription factors bind to this element, including the protein CREB, which is activated as a result of phosphorylation by protein kinase A. It has been shown that protein kinase A-mediated CREB phosphorylation results in its binding to a nuclear protein designated CBP (for CREB-binding protein). These findings suggest that CBP has many of the properties expected of a CREB co-activator. Another high molecular weight transcriptional adapter protein, designated p300, is characterized by three cysteine- and histidine-rich regions, of which the most carboxy terminal region specifically binds the adenovirus E1A protein. p300 molecules lacking an intact E1A binding site bypass E1A repression, even in the presence of high concentrations of E1A. Sequence analysis of CBP and p300 has revealed substantial homology, arguing that these proteins are members of a conserved family of co-activators.
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
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