Caspase Inhibitor X (CAS 848782-29-6)

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Alternativa namn: BI-9B12

Ansökan Caspase Inhibitor X is a competitive inhibitor of caspase-3, caspase-7 and caspase-8

CAS Nr: 848782-29-6

Molekylvikt: 363.4

Molekylär formel: C₁₈H₁₂F₃NO₂S

For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.

* Refer to Certificate of Analysis for lot specific data (including water content).

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Caspase inhibitor X is a non-peptide reversible and competitive inhibitor of caspase-3, caspase-7 and caspase-8 (K_i = 4.3 µM, 6.2 µM and 2.7 µM, respectively). The benzodioxane moiety is shown to fit in the 'aspartate hole' of the caspase. Caspase inhibitor X has been shown to potentially disrupt caspase-8-assisted cleavage of BID. This compound weakly affects the metalloprotease activity of anthrax lethal factor (~ 20 µM).

Konferenser

1. Fattorusso, R., et al. 2005. J. Med. Chem. 48:1649-1656. PMID: 15743206

Physical State :

Solid

Solubility :

Soluble in DMSO (5 mg/ml), and methanol (5 mg/ml).

LAGRING :

Store at 4° C

Melting Point :

184.18° C (Predicted)

Boiling Point :

470.87° C at 760 mmHg (Predicted)

Density :

1.38 g/cm³ (Predicted)

Refractive Index :

n²⁰_D 1.58 (Predicted)

IC50 :

Caspase-3: IC₅₀ = 8.6 µM (human)

Ki Data :

caspase-3: K_i= 4.3 µM; caspase-7: K_i= 6.2 µM; caspase--8: K_i= 2.7 µM

pK Values :

pK_b: 1.20

For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.

PubChem CID :

608841

SMILES :

C1C(OC2=CC=CC=C2O1)C3=NC(=CS3)C4=CC(=CC=C4)C(F)(F)F

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Certificate of Analysis

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