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Caspase Inhibitor X | CAS 848782-29-6 | SCBT - Santa Cruz Biotechnology
Caspase Inhibitor X CAS: 848782-29-6
MF: C18H12F3NO2S
MW: 363.4
A competitive inhibitor of caspase-3, caspase-7 and caspase-8.

Caspase Inhibitor X (CAS 848782-29-6)

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Alternativa namn: BI-9B12
Ansökan Caspase Inhibitor X is a competitive inhibitor of caspase-3, caspase-7 and caspase-8
CAS Nr: 848782-29-6
Molekylvikt: 363.4
Molekylär formel: C18H12F3NO2S
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data (including water content).
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Caspase inhibitor X is a non-peptide reversible and competitive inhibitor of caspase-3, caspase-7 and caspase-8 (Ki = 4.3 µM, 6.2 µM and 2.7 µM, respectively). The benzodioxane moiety is shown to fit in the 'aspartate hole' of the caspase. Caspase inhibitor X has been shown to potentially disrupt caspase-8-assisted cleavage of BID. This compound weakly affects the metalloprotease activity of anthrax lethal factor (~ 20 µM).


Konferenser

1. Fattorusso, R., et al. 2005. J. Med. Chem. 48:1649-1656. PMID: 15743206

Physical State :
Solid
Solubility :
Soluble in DMSO (5 mg/ml), and methanol (5 mg/ml).
LAGRING :
Store at 4° C
Melting Point :
184.18° C (Predicted)
Boiling Point :
470.87° C at 760 mmHg (Predicted)
Density :
1.38 g/cm3 (Predicted)
Refractive Index :
n20D 1.58 (Predicted)
IC50 :
Caspase-3: IC50 = 8.6 µM (human)
Ki Data :
caspase-3: Ki= 4.3 µM; caspase-7: Ki= 6.2 µM; caspase--8: Ki= 2.7 µM
pK Values :
pKb: 1.20
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
PubChem CID :
SMILES :
C1C(OC2=CC=CC=C2O1)C3=NC(=CS3)C4=CC(=CC=C4)C(F)(F)F

Download SDS (MSDS)

Certificate of Analysis

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Caspase Inhibitor X (CAS 848782-29-6)  Produkt Citat

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