caspase-9 inhibitor I (CAS 210345-04-3)
Caspase-9 inhibitor I (Z-LE(OMe)HD(OMe)-FMK) is a cell-permeable, and irreversible inhibitor of caspase-9 that may also inhibit caspase-4 and caspase-5 as well. Caspase inhibitors play an important role in investigating biological processes. The caspase family of proteins function as key components of the apoptotic machinery and act to destroy specific target proteins which are critical to cellular longevity. Standard apoptosis assays can then be used to examine treated cells for evidence of apoptosis.
For the fluorometric determination of caspase-6 activity, the following caspase apoptosis detection kit is available from Santa Cruz: Caspase-6 Kit (sc-4266 AK).
Konferenser
1. Nicholson, D.W. and Thornberry, N.A. 1997. Caspases: killer proteases. Trends Biochem. Sci. 22(8): 299-306. PMID: 9270303
2. Thornberry, N.A. and Lazebnik, Y. 1998. Caspases: enemies within. Science. 281(5381): 1312-1316. PMID: 9721091
3. Fadeel, B., Hassan, Z., Hellström-Lindberg, E., Henter, J.I., Orrenius, S. and Zhivotovsky, B. 1999. Cleavage of Bcl-2 is an early event in chemotherapy-induced apoptosis of human myeloid leukemia cells. Leukemia. 13(5): 719-728. PMID: 10374876
4. Bian, Z.M., Elner, S.G. and Elner, V.M. 2009. Dual involvement of caspase-4 in inflammatory and ER stress-induced apoptotic responses in human retinal pigment epithelial cells. Invest. Ophthalmol. Vis. Sci. 50(12): 6006-6014. PMID: 19643964
• Recommended final working concentration: 50 nM to 100 μM. Investigator must establish the most
effective concentration for their particular assay.
• Following reconstitution, aliquot and freeze (-20°C); stable for up to 3 months at -20°C.
Download SDS (MSDS)
SAMPLE Certificate of Analysis (COA)
caspase-9 inhibitor I | CAS 210345-04-3 SAMPLE Certificate of AnalysisCertificate of Analysis
SAMPLE Certificate of Analysis (COA)
| Test | Specification | Results |
|---|---|---|
| Appearance | White to light brown solid | |
| Identification (NMR) | Consistent with structure | |
| Purity (TLC) | Single spot |
TEST CONDITIONS
Exp. Date: 8/13/2024
caspase-9 inhibitor I (CAS 210345-04-3) Produkt Citat
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