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Caspase-3 Inhibitor III | CAS 285570-60-7 | SCBT - Santa Cruz Biotechnology
Caspase-3 Inhibitor III CAS: 285570-60-7
MF: C21H31ClN4O11
MW: 550.94
A potent cell-permeable and irreversible caspase-3 inhibitor.

Caspase-3 Inhibitor III (CAS 285570-60-7)

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Ansökan Caspase-3 Inhibitor III is a potent cell-permeable and irreversible caspase-3 inhibitor
CAS Nr: 285570-60-7
Molekylvikt: 550.94
Molekylär formel: C21H31ClN4O11
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data (including water content).
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Caspase-3 Inhibitor III (Ac-DEVD-CMK) is a potent cell-permeable and irreversible inhibitor of caspase-3, which is a member of the ICE-CED-3 family of cysteine proteases. Caspase inhibitors play an important role in investigating biological processes. The caspase family of proteins function as key components of the apoptotic machinery and act to destroy specific target proteins which are critical to cellular longevity. Following use of the inhibitor, standard apoptosis assays can then be used to examine treated cells for evidence of apoptosis.

For the fluorometric determination of caspase-3 activity, the following caspase apoptosis detection kit is available from Santa Cruz: Caspase-3 Kit (sc-4263 AK). Caspase-3 Inhibitor III is an inhibitor of caspase-10, caspase-6, caspase-7 and caspase-8.


Konferenser

1. Mocanu, M.M., et al. 2000. Br. J. Pharmacol. 130: 197-200. PMID: 10807653
2. Schrantz, N., et al. 1999. Cell Death Differ. 6: 445-453. PMID: 10381635
3. Thornberry, N.A. and Lazebnik, Y. 1998. Science. 281: 1312-1316. PMID: 9721091
4. Zhang, Y., et al. 2004. J. Neurosc. 24: 10616-10627. PMID: 15564577

Physical State :
Solid
Sequence :
Ac-Asp-Glu-Val-Asp-CMK
Solubility :
Soluble in DMSO (50 mg/ml).
LAGRING :
Store at -20° C
Boiling Point :
1048.1° C at 760 mmHg (Predicted)
Density :
1.4 g/cm3 (Predicted)
IC50 :
Caspase-3: IC50 = 13.4 µM (human)
pK Values :
pKa: 3.93 (Predicted)
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
PubChem CID :
SMILES :
CC(C)[[email protected]@H](C(=O)N[[email protected]@H](CC(=O)O)C(=O)CCl)NC(=O)[[email protected]](CCC(=O)O)NC(=O)[[email protected]](CC(=O)O)NC(=O)C

Download SDS (MSDS)

Certificate of Analysis

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Caspase-3 Inhibitor III (CAS 285570-60-7)  Produkt Citat

See how others have used Caspase-3 Inhibitor III (CAS 285570-60-7). Click on the entry to view the PubMed entry .

Citations 1 to 5 of 5 total

PMID: 25367763 | Differential impact of bortezomib on HL-60 and K562 cells. | Kliková, K. et al. 2015. General physiology and biophysics. 34: 33-42.

PMID: 32104529 |  | Oxid Med Cell Longev. 2563764.

Citations 1 to 5 of 5 total
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