caspase-1 inhibitor
Caspase-1 inhibitor is a cell-permeable inhibitor of caspase-1 (also known as ICE or Interleukin-1β Converting Enzyme), caspase-4, and caspase-5. The C-terminal sequence (YVAD-CHO) of this peptide is a highly specific, potent, and reversible inhibitor of caspase-1 (Ki = 1 nM). The N-terminal amino acid residues 1-16 correspond to the hydrophobic region of the signal peptide of the Kaposi fibroblast growth factor (K-FGF) and confer cell-permeability to the peptide.
Konferenser
1. Thornberry, N.A., et al. 1992. Nature. 356: 768-774. PMID: 1574116
2. Thornberry, N.A., et al. 1994. Biochemistry. 33: 3934-3940. PMID: 8142397
3. Thornberry, N.A., 1994. Meth. Enzymol. 244: 615-631. PMID: 7845238
4. Lin, Y.Z., et al. 1995. J. Biol. Chem. 270: 14255-14258. PMID: 7782278
5. Lin, Y.Z., et al. 1996. J. Biol. Chem. 271: 5305-5308. PMID: 8621379
6. Garcia-Calvo, M., et al. 1998. J. Biol. Chem. 273: 32608-32613. PMID: 9829999
7. Thornberry, N.A. 1998. Science. 281: 1312-1316. PMID: 9721091
Download SDS (MSDS)
SAMPLE Certificate of Analysis (COA)
caspase-1 Inhibitor SAMPLE Certificate of AnalysisCertificate of Analysis
SAMPLE Certificate of Analysis (COA)
| Test | Specification | Results |
|---|---|---|
| Appearance | Lyophilized solid | |
| Purity (HPLC) | 99% | |
| Peptide Content | 90.3% |
TEST CONDITIONS
Exp. Date: 9/19/2024
caspase-1 inhibitor Produkt Citat
See how others have used caspase-1 inhibitor. Click on the entry to view the PubMed entry .
PMID: 25174821 | Naringin inhibits growth and induces apoptosis by a mechanism dependent on reduced activation of NF-κB/COX-2-caspase-1 pathway in HeLa cervical cancer cells. | Zeng, L. et al. 2014. Int. J. Oncol. 45: 1929-36.