Caspase-1 inhibitor VI
Caspase-1 inhibitor VI (Z-YVAD-FMK) is a cell-permeable, irreversible inhibitor of caspase-1, caspase-4, and caspase-5 activity. Caspase inhibitors play an important role in investigating biological processes. The caspase family of proteins function as key components of the apoptotic machinery and act to destroy specific target proteins which are critical to cellular longevity. Caspase-1, originally designated ICE (for IL-1 converting enzyme), is a member of the group of caspases with large prodomains. Active caspase-1, a (p20/p10)2 tetramer, is necessary and sufficient for cleavage of precursor IL-1 as well as for induction of apoptosis in some cell lines. Following use of the inhibitor, standard apoptosis assays can be used to examine treated cells for evidence of apoptosis.
Additional caspase-1 inhibitors available:
Caspase-1 inhibitor (sc-3069)
Caspase-1 Inhibitor II (sc-300323)
Caspase-1 Inhibitor IV (sc-300324)
Caspase-1 Inhibitor I (sc-358878)
Konferenser
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Prepare a 10mM stock solution of the caspase inhibitor in high quality DMSO.
Store solution aliquots at -20°C.
Download SDS (MSDS)
SAMPLE Certificate of Analysis (COA)
Caspase-1 inhibitor VI SAMPLE Certificate of AnalysisCertificate of Analysis
SAMPLE Certificate of Analysis (COA)
| Test | Specification | Results |
|---|---|---|
| Appearance | White powder | |
| Identification (NMR) | Consistent with structure | |
| Purity (TLC) | ≥ 98% |
Caspase-1 inhibitor VI Produkt Citat
See how others have used Caspase-1 inhibitor VI. Click on the entry to view the PubMed entry .
PMID: 35931812 | Macrophages in obesity are characterised by increased IL-1β response to calcium-sensing receptor signals. | Thrum, S. et al. 2022. Int J Obes (Lond).
PMID: 32194260 | Tumor necrosis factor primes and metal particles activate the NLRP3 inflammasome in human primary macrophages. | Jämsen, E. et al. 2020. Acta Biomater. 108: 347-357.
PMID: 30692621 | SERPINB1-mediated checkpoint of inflammatory caspase activation. | Choi, YJ. et al. 2019. Nat. Immunol. 20: 276-287.
PMID: 29601578 | HIV induces production of IL-18 from intestinal epithelial cells that increases intestinal permeability and microbial translocation. | Allam, O. et al. 2018. PLoS ONE. 13: e0194185.
PMID: 29193391 | Dihydromyricetin inhibits NLRP3 inflammasome-dependent pyroptosis by activating the Nrf2 signaling pathway in vascular endothelial cells. | Hu, Q. et al. 2018. Biofactors. 44: 123-136.
PMID: 30167087 | Paradoxical counteraction by imatinib against cell death in myeloid progenitor 32D cells expressing p210BCR-ABL. | Takita, M. et al. 2018. Oncotarget. 9: 31682-31696.
PMID: 27914933 | Differential synthesis and release of IL-18 and IL-18 Binding Protein from human platelets and their implications for HIV infection. | Allam, O. et al. 2017. Cytokine. 90: 144-154.
PMID: 28871042 | Trimethylamine-N-Oxide Induces Vascular Inflammation by Activating the NLRP3 Inflammasome Through the SIRT3-SOD2-mtROS Signaling Pathway. | Chen, ML. et al. 2017. J Am Heart Assoc. 6:
PMID: 26809137 | Cadmium induces NLRP3 inflammasome-dependent pyroptosis in vascular endothelial cells. | Chen, H. et al. 2016. Toxicol. Lett. 246: 7-16.
PMID: 27452236 | A Salmonella nanoparticle mimic overcomes multidrug resistance in tumours. | Mercado-Lubo, R. et al. 2016. Nat Commun. 7: 12225.