Caspase-1 inhibitor I CAS: 143313-51-3
MF: C23H32N4O8
MW: 492.52
An inhibitor of caspase-1, caspase-4, and caspase-5.

Caspase-1 inhibitor I (CAS 143313-51-3)

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Alternativa namn: N-Ac-Tyr-Val-Ala-Asp-CHO; Ac-YVAD-CHO
Ansökan Caspase-1 inhibitor I is an inhibitor of caspase-1, caspase-4, and caspase-5
CAS Nr: 143313-51-3
Renhet: ≥95%
Molekylvikt: 492.52
Molekylär formel: C23H32N4O8
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data (including water content).
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Caspase-1 Inhibitor I (Ac-YVAD-CHO, also designated L-709049) is a potent, specific, reversible inhibitor of caspase-1 (Ki = 200 pM for human recombinant caspase-1), caspase-4, and caspase-5. Caspase inhibitors play an important role in investigating biological processes. The caspase family of proteins function as key components of the apoptotic machinery and act to destroy specific target proteins which are critical to cellular longevity. Caspase-1, originally designated ICE (for IL-1 converting enzyme), is a member of the group of caspases with large prodomains. Active caspase-1, a (p20/p10)2 tetramer, is necessary and sufficient for cleavage of precursor IL-1 as well as for induction of apoptosis in some cell lines. Ac-YVAD-CHO has been shown to strongly inhibit anti-APO-1 induced apoptosis in L929-APO-1 cells. Following use of the inhibitor, standard apoptosis assays can be used to examine treated cells for evidence of apoptosis.

Additional caspase-1 inhibitors available:
caspase-1 inhibitor (sc-3069)
caspase-1 inhibitor VI (sc-3071)
Caspase-1 Inhibitor II (sc-300323)
Caspase-1 Inhibitor IV (sc-300324)


Konferenser

1. Brenner, B., et al. 1998. Cell Death Differ. 5: 29-37. PMID: 10200443
2. Garcia-Calvo, M., et al. 1998. J. Biol. Chem. 273: 32608-32613. PMID: 9829999
3. Hilbi, H., et al. 1998. J. Biol. Chem. 273: 32895-32900. PMID: 9830039
4. Thornberry, N.A, et al. 1998. Science. 281: 1312-1316. PMID: 9721091
5. Schlegel, J., et al. 1996. J. Biol. Chem. 271: 1841-1844. PMID: 8567626
6. Enari, M., et al. 1995. Nature. 375: 78-81. PMID: 7536900
7. Walker, N.P., et al. 1994. Cell. 78: 343-352. PMID: 8044845
8. Thornberry, N.A., et al. 1992. Nature. 356: 768-774. PMID: 1574116

Usage :
Aqueous solutions should not be stored more than 1 day.
Physical State :
Solid
Solubility :
Soluble in DMSO (5 mg/ml), water (5 mg/ml) at 25° C, ethanol (~30 mg/ml), DMF (~30 mg/ml), and PBS(pH 7.2) (~5 mg/ml).
LAGRING :
Store at -20° C
Melting Point :
349.84° C (Predicted)
Boiling Point :
~937.75° C at 760 mmHg (Predicted)
Density :
~1.3 g/cm3 (Predicted)
Refractive Index :
n20D 1.55 (Predicted)
IC50 :
Caspase-1: IC50 = 8.4 nM (human); PBMC : IC50 = 1.2 µM (human); Interleukin-1 beta: IC50 = 2 µM (human)
Ki Data :
recombinant caspase-1: Ki= 200 pM (human); Caspase-1: Ki= 9 nM (mouse)
pK Values :
pKb: 4.20 (Predicted)
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
WGK Germany :
3
PubChem CID :
MDL Number :
MFCD00237123
SMILES :
C[[email protected]@H](C(=O)N[[email protected]@H](CC(=O)O)C=O)NC(=O)[[email protected]](C(C)C)NC(=O)[[email protected]](CC1=CC=C(C=C1)O)NC(=O)C

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Certificate of Analysis

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Caspase-1 inhibitor I (CAS 143313-51-3)  Produkt Citat

See how others have used Caspase-1 inhibitor I (CAS 143313-51-3). Click on the entry to view the PubMed entry .

Citations 1 to 10 of 11 total

PMID: # 29446207  Zhao, H.|Huang, H.|Alam, A.|Chen, Q.|Suen, KC.|Cui, J.|Sun, Q.|Ologunde, R.|Zhang, W.|Lian, Q.|Ma, D.| et al. 2018. Am. J. Transplant. 18: 1890-1903.

PMID: # 26901245  Xia, X. et al. 2016. Chemical research in toxicology. 29: 421-9.

PMID: # 27628063  Winges, A. et al. 2016. Graefes Arch. Clin. Exp. Ophthalmol. 254: 2387-2400.

PMID: # 26086368  Liang, Y. et al. 2015. Brain Res. 1622: 43-50.

PMID: # 24340123  Tavares, AH. et al. 2013. PLoS Negl Trop Dis. 7: e2595.

PMID: # 17235324  Park, HJ. et al. 2007. J Invest Dermatol. 127(5): 1210-1216.

PMID: # 28436935  J. Clin. Invest. 127: 2222-2234.

PMID: # 32721574  Toxicol. Lett.

PMID: # 32742397  Exp Ther Med. 1675-1681.

PMID: # 29209318  Front Immunol. 1572.

Citations 1 to 10 of 11 total
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