Carmustine (CAS 154-93-8)

5.0(1)

Alternativa namn: 1,3-bis(2-chloroethyl)-1-nitrosourea; Nitrumon; Carmubris; Gliadel

Ansökan Carmustine is a DNA alkylating and cross-linking agent used in the treatment of brain tumors and various other malignant neoplasms

CAS Nr: 154-93-8

Renhet: ≥96%

Molekylvikt: 214.05

Molekylär formel: C₅H₉Cl₂N₃O₂

Kompletterande information: This is classified as a Dangerous Good for transport and may be subject to additional shipping charges.

For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.

* Refer to Certificate of Analysis for lot specific data (including water content).

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Carmustine is a member of the antineoplastic nitrosourea compounds. Carmustine can perform both alkylating and carabamoylating action and owes part of its cytotoxicity to its demonstrated ability to produce interstrand DNA cross linking. In addition, this compound has been documented as an inhibitor of glutathione reductase, trypanothione reductase, and lipoamide dehydrogenase (DLD).

Konferenser

1. Schabel, F.M. 1976. Cancer Treat Rep. 60: 665-698. PMID: 782694
2. Puglia, C.D., et al. 1984. Environ. Health Perspect. 57: 307-311. PMID: 6094175
3. Lohrer, H. and Krauth-Siegel, R.L. 1990. Eur. J. Biochem. 194: 863-869. PMID: 2269305
4. Arscott, L.D., et al. 1997. Proc. Natl. Acad. Sci. U.S.A. 94: 3621-3626. PMID: 9108027
5. Pratt, B.W., et al. 1994. The Anticancer Drugs. Oxoford Universtiy Press Inc. N.Y., N.Y.

Physical State :

Low-Melting Solid

Solubility :

Soluble in water (4 mg/ml), and 50% ethanol (150 mg/ml).

LAGRING :

Store at -20° C

Melting Point :

30° C (lit.)

Boiling Point :

333.07° C (Predicted)

Density :

~1.50 g/cm³ (Predicted)

Refractive Index :

n²⁰_D 1.55 (Predicted)

IC50 :

U-87 MG: IC₅₀ = 1.42 µM (human); L1210: IC₅₀ = 4.50 µM (mouse); MCF7: IC₅₀ = 4.50 µM (human); NCI-H23: IC₅₀ = 5.00 µM (human); P388: IC₅₀ = 5.90 µM (human)

pK Values :

pK_a: 10.19 (Predicted)

For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.

WGK Germany :

RTECS :

YS2625000

PubChem CID :

2578

Merck Index :

14: 1845

MDL Number :

MFCD00057706

EC Number :

205-838-2

SMILES :

C(CCl)NC(=O)N(CCCl)N=O

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Certificate of Analysis

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Carmustine (CAS 154-93-8) Produkt Citat

See how others have used Carmustine (CAS 154-93-8). Click on the entry to view the PubMed entry .

Citations 1 to 1 of 1 total

PMID: # 30014903 Shen, M. et al. 2018. Redox Biol. 18: 138-157.

Citations 1 to 1 of 1 total

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