Carmustine is a member of the antineoplastic nitrosourea compounds. Carmustine can perform both alkylating and carabamoylating action and owes part of its cytotoxicity to its demonstrated ability to produce interstrand DNA cross linking. In addition, this compound has been documented as an inhibitor of glutathione reductase, trypanothione reductase, and lipoamide dehydrogenase (DLD).
1. Schabel, F.M. 1976. Cancer Treat Rep. 60: 665-698. PMID: 782694 2. Puglia, C.D., et al. 1984. Environ. Health Perspect. 57: 307-311. PMID: 6094175 3. Lohrer, H. and Krauth-Siegel, R.L. 1990. Eur. J. Biochem. 194: 863-869. PMID: 2269305 4. Arscott, L.D., et al. 1997. Proc. Natl. Acad. Sci. U.S.A. 94: 3621-3626. PMID: 9108027 5. Pratt, B.W., et al. 1994. The Anticancer Drugs. Oxoford Universtiy Press Inc. N.Y., N.Y.
Soluble in water (4 mg/ml), and 50% ethanol (150 mg/ml).
To place an order using RMB or to ship to mainland China, please visit www.scbio.cn