Carmustine CAS: 154-93-8
MF: C5H9Cl2N3O2
MW: 214.05
A DNA alkylating and cross-linking agent used in the treatment of brain tumors and various other malignant neoplasms.

Carmustine (CAS 154-93-8)

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Alternativa namn: 1,3-bis(2-chloroethyl)-1-nitrosourea; Nitrumon; Carmubris; Gliadel
Ansökan Carmustine is a DNA alkylating and cross-linking agent used in the treatment of brain tumors and various other malignant neoplasms
CAS Nr: 154-93-8
Renhet: ≥96%
Molekylvikt: 214.05
Molekylär formel: C5H9Cl2N3O2
Kompletterande information: This is classified as a Dangerous Good for transport and may be subject to additional shipping charges.
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data (including water content).

Carmustine is a member of the antineoplastic nitrosourea compounds. Carmustine can perform both alkylating and carabamoylating action and owes part of its cytotoxicity to its demonstrated ability to produce interstrand DNA cross linking. In addition, this compound has been documented as an inhibitor of glutathione reductase, trypanothione reductase, and lipoamide dehydrogenase (DLD).


Konferenser

1. Schabel, F.M. 1976. Cancer Treat Rep. 60: 665-698. PMID: 782694
2. Puglia, C.D., et al. 1984. Environ. Health Perspect. 57: 307-311. PMID: 6094175
3. Lohrer, H. and Krauth-Siegel, R.L. 1990. Eur. J. Biochem. 194: 863-869. PMID: 2269305
4. Arscott, L.D., et al. 1997. Proc. Natl. Acad. Sci. U.S.A. 94: 3621-3626. PMID: 9108027
5. Pratt, B.W., et al. 1994. The Anticancer Drugs. Oxoford Universtiy Press Inc. N.Y., N.Y.

Physical State :
Low-Melting Solid
Solubility :
Soluble in water (4 mg/ml), and 50% ethanol (150 mg/ml).
LAGRING :
Store at -20° C
Melting Point :
30° C (lit.)
Boiling Point :
333.07° C (Predicted)
Density :
~1.50 g/cm3 (Predicted)
Refractive Index :
n20D 1.55 (Predicted)
IC50 :
U-87 MG: IC50 = 1.42 µM (human); L1210: IC50 = 4.50 µM (mouse); MCF7: IC50 = 4.50 µM (human); NCI-H23: IC50 = 5.00 µM (human); P388: IC50 = 5.90 µM (human)
pK Values :
pKa: 10.19 (Predicted)
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
WGK Germany :
3
RTECS :
YS2625000
PubChem CID :
Merck Index :
14: 1845
MDL Number :
MFCD00057706
EC Number :
205-838-2
SMILES :
C(CCl)NC(=O)N(CCCl)N=O

Download SDS (MSDS)

Certificate of Analysis

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Carmustine (CAS 154-93-8)  Produkt Citat

See how others have used Carmustine (CAS 154-93-8). Click on the entry to view the PubMed entry .

Citations 1 to 1 of 1 total

PMID: # 30014903  Shen, M. et al. 2018. Redox Biol. 18: 138-157.

Citations 1 to 1 of 1 total
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