Canrenone CAS: 976-71-6
MF: C22H28O3
MW: 340.46
An inhibitor of aldosterone biosynthesis and ouabain.

Canrenone (CAS 976-71-6)

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Alternativa namn: Phanurane; Aldadiene; Luvion
Ansökan Canrenone is an inhibitor of aldosterone biosynthesis and ouabain
CAS Nr: 976-71-6
Renhet: ≥97%
Molekylvikt: 340.46
Molekylär formel: C22H28O3
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data (including water content).

Canrenone is an active metabolite of spironolactone that acts as an MCR antagonist, inhibiting aldosterone biosynthesis. it also blocks ouabain effects.


Konferenser

1. Cittadini, A., et al. 2003. Cardiovasc. Res. 58: 555-564. PMID: 12798428
2. Balzan, S., et al. 2003. J. Cardiovasc. Pharmacol. 42: 32-36. PMID: 12827023
3. Datta, P. and Dasgupta, A. 2003. Ther. Drug Monit. 25: 478-482. PMID: 12883233

Appearance :
Powder
Physical State :
Solid
Solubility :
Soluble in DMSO (100 mM), chloroform, acetone, water(does not mix well), and methanol.
LAGRING :
Store at 4° C
Melting Point :
149-151° C
Refractive Index :
n20D 1.58 (Predicted)
Optical Activity :
α20/D +24.5° in chloroform; α20/D +19.5°, c = 1 in chloroform
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
RTECS :
TU3493000
PubChem CID :
Merck Index :
14: 1752
MDL Number :
MFCD00071735
EC Number :
213-554-5
Beilstein Registry :
0046602

Download SDS (MSDS)

Certificate of Analysis

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Canrenone (CAS 976-71-6)  Produkt Citat

See how others have used Canrenone (CAS 976-71-6). Click on the entry to view the PubMed entry .

Citations 1 to 2 of 2 total

PMID: # 28743784  Wehr, MC.|Hinrichs, W.|Brzózka, MM.|Unterbarnscheidt, T.|Herholt, A.|Wintgens, JP.|Papiol, S.|Soto-Bernardini, MC.|Kravchenko, M.|Zhang, M.|Nave, KA.|Wichert, SP.|Falkai, P.|Zhang, W.|Schwab, MH.|Rossner, MJ.| et al. 2017. EMBO Mol Med. 9: 1448-1462.

PMID: # 28666228  van der Nagel, BCH. et al. 2017. J. Chromatogr. B Analyt. Technol. Biomed. Life Sci. 1060: 367-373.

Citations 1 to 2 of 2 total
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