Camptothecin was originally isolated from the stem wood of the Camptotheca acuminata tree and was shown to exhibit antileukemic/antitumor activity, and reversibly inhibit Mitochondrial Topo I (nuclear Topo I (topoisomerase I)) by binding to and stabilizing the topoisomerase-DNA covalent complex. Advancing replication forks are believed to interact with these complexes leading to double strand breaks, which is thought to be responsible for much of the cytotoxicity; other research has shown that some of the antitumor activity could be derived from the inhibition of NOS2 (iNOS or inducible nitric oxide synthase) which generates nitric oxide, an important regulator of angiogenesis and other biochemical pathways. The discovery of camptothecin spurred the development of many derivatives with superior activity and solubility, including irinotecan (sc-202186) and topotecan (sc-204919). Although most noted for its anticancer activity, camptothecin and derivatives have shown other pertinent biochemical actions, including: antiprotozoal, antimalarial, inhibition of HIV, upregulation of p53, and induction of apoptosis. This product also exhibits intense blue fluorescence when exposed to UV light, which could be useful in optical experiments.
1. Hertzberg, R.P., et al. 1990. J. Biol. Chem. 265: 19287-19295. PMID: 2172250
2. Slichenmyer, W.J., et al. 1993. J. Natl. Cancer Inst. 85: 271-291. PMID: 8381186
3. Tanizawa, A., et al. 1995. Biochemistry. 34: 7200-7206. PMID: 7766631
4. Ljungman, M., et al. 1996. Carcinogenesis. 17: 31-35. PMID: 8565133
5. Suzuki, A., et al. 1996. Exp. Cell Res. 227: 154-159. PMID: 8806462
6. Shimizu, T., et al. 1997. Leukemia. 11: 1238-1244. PMID: 9264376
7. Pommier, Y., et al. 1998. Biochim. Biophys. Acta. 1400: 83-105. PMID: 9748515
8. Chiou, W.F., et al. 2001. Life Sci. 69: 625-635. PMID: 11476184
9. Sriram, D., et al. 2005. Nat. Prod. Res. 19: 393-412. PMID: 15938148
See how others have used Camptothecin. Click on the entry to view the PubMed entry .
PMID: # 30514321 Tan, SN. et al. 2018. BMC Mol. Biol. 19: 15.
PMID: # 30213795 Funato, K.|Hayashi, T.|Echizen, K.|Negishi, L.|Shimizu, N.|Koyama-Nasu, R.|Nasu-Nishimura, Y.|Morishita, Y.|Tabar, V.|Todo, T.|Ino, Y.|Mukasa, A.|Saito, N.|Akiyama, T.| et al. 2018. EMBO Rep. 19:
PMID: # 29031818 Khageh Hosseini, S. et al. 2017. Biochem. Pharmacol. 146: 53-62.
PMID: # 27852435 Lopez-Mosqueda, J. et al. 2016. Elife. 5:
PMID: # 26703711 Claus, C. et al. 2015. Viruses. 7: 6108-26.
PMID: # 25525250 Funato, K. et al. 2014. Science. 346: 1529-33.
PMID: # 22851130 Gillies, AT. et al. 2012. Molecular bioSystems. 8: 2901-8.
PMID: # 17965250 Legrand, M. et al. 2007. Eukaryotic Cell. 6: 2194-2205.
PMID: # 17515603 Seiler, JA. et al. 2007. Mol. Cell. Biol. 27: 5806-5818.
PMID: # 17030995 Malavazi, I. et al. 2006. Eukaryotic Cell. 5: 1688-1704.
Santa Cruz Biotechnology, Inc. is a world leader in the development of products for the biomedical research market. Call us Toll Free at 1-800-457-3801.
Copyright © 2007-2020 Santa Cruz Biotechnology, Inc. All Rights Reserved. "Santa Cruz Biotechnology", and the Santa Cruz Biotechnology, Inc. logo, "Santa Cruz Animal Health", "San Juan Ranch", "Supplement of Champions", the San Juan Ranch logo, "Ultracruz", "Chemcruz", "Immunocruz", "Exactacruz", and "EZ Touch" are registered trademarks of Santa Cruz Biotechnology, Inc.
All trademarks are the property of their respective owners.