Bupropion HCl CAS: 31677-93-7
MF: C13H18ClNO•HCl
MW: 276.2
An inhibitor of dopamine and SLC6A2.

Bupropion HCl (CAS 31677-93-7)

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Alternativa namn: 1-(3-chlorophenyl)-2-[(1,1-dimethylethyl)amino]-1-propane, monohydrochloride
Ansökan Bupropion HCl is an inhibitor of dopamine and SLC6A2
CAS Nr: 31677-93-7
Renhet: ≥99%
Molekylvikt: 276.2
Molekylär formel: C13H18ClNO•HCl
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data (including water content).

Bupropion HCl is a non-selective inhibitor of dopamine and SLC6A2 (Ki values are 1.4 μM for SLC6A2, 2.8 μM for dopamine, and 45 μM for serotonin). Bupropion also inhibits neuronal nicotinic acetylcholine receptors. Bupropion HCl is an inhibitor of AChR, DAT and ST.


Konferenser

1. Cooper, B.R., et al. 1980. J. Pharmacol. Exp. Ther. 215: 127-134. PMID: 6778989
2. Lerman, C., et al. 2005. J. Clin. Oncol. 23: 311-323. PMID: 15637394
3. Silverstone, P.H., et al. 2008. Ann Gen Psychiatry. 7: 11. PMID: 18706108
4. Papakostas, G.I., et al. 2008. J Clin Psychiatry. 69: 1287-1292. PMID: 18605812
5. Henshall, D.C., et al. 2009. Neuropsychiatr Dis Treat. 5: 189-206. PMID: 19557114

Appearance :
Powder
Physical State :
Solid
Solubility :
Soluble in water (>25 mg/ml), ethanol 193mg/ml, 0.1 N HCl 333 mg/ml
LAGRING :
Store at 4° C
Melting Point :
236-238° C
Ki Data :
serotonin transporter : Ki= 45 µM; dopamine transporter: Ki= 2.8 µM; norepinephrine transporters: Ki= 1.4 µM
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
WGK Germany :
3
RTECS :
UG8858000
PubChem CID :
Merck Index :
14: 1499
MDL Number :
MFCD00055209
EC Number :
250-759-9
SMILES :
CC(C(=O)C1=CC(=CC=C1)Cl)NC(C)(C)C.Cl

Download SDS (MSDS)

Certificate of Analysis

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Bupropion HCl (CAS 31677-93-7)  Produkt Citat

See how others have used Bupropion HCl (CAS 31677-93-7). Click on the entry to view the PubMed entry .

Citations 1 to 3 of 3 total

PMID: # 25616031  Hall, BJ. et al. 2015. Pharmacology, biochemistry, and behavior. 130: 84-9.

PMID: # 25249693  Wu, J. et al. 2014. Drug Metab. Dispos. 42: 2058-67.

PMID: # 23751335  Writer, JH. et al. 2013. Sci. Total Environ. 461-462: 519-27.

Citations 1 to 3 of 3 total
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