BMS 470539 dihydrochloride CAS: 457893-92-4
MF: C32H41N5O4•2HCl
MW: 632.62
A selective and potent agonist of melanocortin receptor (MC1-R).

BMS 470539 dihydrochloride (CAS 457893-92-4)

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Alternativa namn: 1-[1-(3-Methyl-L-histidyl-O-methyl-D-tyrosyl)-4-phenyl-4-piperidinyl]-1-butanone dihydrochloride
Ansökan BMS 470539 dihydrochloride is a selective and potent agonist of melanocortin receptor (MC1-R)
Momsregistreringsnummer :: 457893-92-4
Molecular Weight: 632.62
Molecular Formula: C32H41N5O42HCl
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data (including water content).

BMS 470539 dihydrochloride is a selective MC1-R (melanocortin receptor) agonist (IC50 = 120 nM). This compound also inhibits leukocyte trafficking and displays anti-inflammatory properties following ischemia-reperfusion in the vasculature.


Konferenser

1. Chen, X., Et al. 2017. Ann Neurol. 81(3): 395-406. PMID: 28019657

Physical State :
Solid
Solubility :
Soluble in water (100 mM), and DMSO (100 mM).
LAGRING :
Desiccate at room temperature
Refractive Index :
n20D 1.61 (Predicted)
IC50 :
MC1-R: EC5050 = 28 nM (human); MC1-R: IC50 = 120 nM; MC4-R: EC5050 = 2.6 µM (human); MC5-R: EC5050 = 4.4 µM (human)
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
PubChem CID :
60210130
MDL Number :
MFCD19690933
SMILES :
CCCC(=O)C1(CCN(CC1)C(=O)[[email protected]@H](CC2=CC=C(C=C2)OC)NC(=O)[[email protected]](CC3=CN=CN3C)N)C4=CC=CC=C4.Cl.Cl

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Certificate of Analysis

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BMS 470539 dihydrochloride (CAS 457893-92-4)  Produkt Citat

See how others have used BMS 470539 dihydrochloride (CAS 457893-92-4). Click on the entry to view the PubMed entry .

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PMID: # 31486022  Neurotherapeutics.

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