Anti-BMPR-II Antibody (E-1): sc-393304

BMPR-II Antibody (E-1) is a high quality monoclonal BMPR-II antibody (also designated Bone Morphogenetic Protein Receptor Type 2 antibody, Bone Morphogenetic Protein Receptor Type II antibody, Serine/Threonine Kinase antibody, Bone Morphogenetic Protein Receptor Type-2 antibody, BMP Type II Receptor antibody, MPR3 antibody, BRK-3 antibody, T-ALK antibody, PPH1 antibody, Type II Activin Receptor-Like Kinase antibody, Primary Pulmonary Hypertension 1 antibody, or POVD1 antibody) suitable for the detection of the BMPR-II protein of mouse, rat and human origin. BMPR-II Antibody (E-1) is available as both the non-conjugated anti-BMPR-II antibody form, as well as multiple conjugated forms of anti-BMPR-II antibody, including agarose, HRP, PE, FITC and multiple Alexa Fluor^® conjugates. Members of the transforming growth factor b superfamily bind to a pair of transmembrane proteins, known as receptor types I and II, which contain serine/threonine kinases and associate to form a signaling complex. Two type I receptors have been characterized, BMPR-IA (also designated SKR5, ALK-3, and BRK-1) and BMPR-IB (also designated ALK-6 and SKR 6), that bind to bone morphogenetic proteins (BMP)-2, BMP-4, and osteogenic protein (OP)-1 (also designated BMP-7). BMPR-IA and BMPR-IB are both expressed in human glioma cell lines. The type II receptor, BMPR-II, efficiently binds to OP-1 and BMP-2 and weakly binds BMP-4, and it is widely expressed in different tissues, including brain (1,5,6). The BMP receptor family members are thought to mediate distinct effects on gene expression, cell differentiation, and morphogenesis in a dose dependent fashion.

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