BIBF1120 CAS: 656247-17-5
MF: C31H33N5O4
MW: 539.62
BIBF1120 is a potent kinase inhibitor found to affect VEGF, PDGF, and FGF receptors.

BIBF1120 (CAS 656247-17-5)

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Alternativa namn: Vargatef; Nintedanib, Free Base
Ansökan BIBF1120 is BIBF1120 is a potent kinase inhibitor found to affect VEGF, PDGF, and FGF receptors
Momsregistreringsnummer :: 656247-17-5
Purity: ≥99%
Molecular Weight: 539.62
Molecular Formula: C31H33N5O4
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data (including water content).

BIBF1120 inhibits PDGFR kinase activity of PDGFR alpha and PDGFR beta types with IC50 values of 59 and 65 nM, respectively. In addition, BIBF1120 suppresses the FGFR subtypes with IC50 of 60, 37 and 108 nM for FGFR1, FGFR2, and FGFR3, respectively. BIBF1120 binds to the ATP-binding site in the cleft between the amino and carboxy terminal lobes of the kinase domain.

Physical State :
Solid
LAGRING :
Store at -20° C
Boiling Point :
~742.2° C at 760 mmHg (Predicted)
Density :
~1.3 g/cm3 (Predicted)
Refractive Index :
n20D 1.66 (Predicted)
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
PubChem CID :
9809715
SMILES :
CN1CCN(CC1)CC(=O)N(C)C2=CC=C(C=C2)N/C(=C\3/C4=C(C=C(C=C4)C(=O)OC)NC3=O)/C5=CC=CC=C5

Download SDS (MSDS)

Certificate of Analysis

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